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자료유형
학술저널
저자정보
Ahn Ari (Department of Laboratory Medicine College of Medicine The Catholic University of Korea Seoul Korea) Park Chan-Jeoung (Department of Laboratory Medicine University of Ulsan College of Medicine and Asan Medical Center S) Kim Min-sun (Department of Laboratory Medicine University of Ulsan College of Medicine and Asan Medical Center S) Cho Young-Uk (Department of Laboratory Medicine University of Ulsan College of Medicine and Asan Medical Center S) Jang Seongsoo (Department of Laboratory Medicine University of Ulsan College of Medicine and Asan Medical Center S) Bae Mi Hyun (Department of Laboratory Medicine Hanyang University Guri Hospital Hanyang University College of Me) Lee Jung-Hee (Department of Internal Medicine University of Ulsan College of Medicine and Asan Medical Center Seo) Lee Je-Hwan (Department of Internal Medicine University of Ulsan College of Medicine and Asan Medical Center Seo) Koh Kyung-Nam (Department of Pediatrics University of Ulsan College of Medicine and Asan Medical Center Seoul Kore) Im Ho Joon (Department of Pediatrics University of Ulsan College of Medicine and Asan Medical Center Seoul Kore)
저널정보
대한진단검사의학회 Annals of Laboratory Medicine Annals of Laboratory Medicine 제41권 제5호
발행연도
2021.9
수록면
479 - 484 (6page)
DOI
10.3343/alm.2021.41.5.479

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Myeloid-derived suppressor cells (MDSCs) represent phenotypically heterogeneous populations that suppress tumor-specific T-cell responses. MDSCs are produced from myeloid precursors in emergent states and are increased in several hematologic malignancies. We evaluated the differences in the levels and prognostic significance of MDSCs according to the clinical status of chronic myeloid leukemia (CML). The percentages and numbers of granulocytic (g)MDSCs and monocytic (m)MDSCs in peripheral blood (PB) and bone marrow (BM) aspirates were determined by five-color flow cytometry (HLA-DR/CD11b/CD15/CD33/CD14). The median BM-gMDSC% and PB-gMDSC% of the CML group were lower than those of the complete hematologic response (CHR) and control groups (P<0.001). In the CHR group, patients with major molecular response (MMR) showed higher median BM-gMDSC% than those without MMR (P=0.039). Conversely, the PB-mMDSC number of the CML group was higher than those of the CHR and control groups (P<0.001). Patients with high PB-gMDSC number exhibited superior survival to those with low PB-gMDSC number (P=0.021), and patients with high PB-mMDSC% showed inferior survival to those with low PB-mMDSC%, but there was no statistical significance (P=0.182). Increased gMDSCs at CHR may reflect non-leukemic granulopoiesis, and a high number of PB-gMDSCs suggests better prognosis in CML. However, mMDSCs may be associated with malignant conditions and poor prognosis.

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