지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 125 - 134 (10page)
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초록· 키워드
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Acute graft-versus-host-disease (GVHD) is characterized by selective damage to the liver, the skin, and the gastrointestinal tract. Following allogeneic hematopoietic stem cell transplantation, donor bone marrow (BM) cells repopulate the immune system of the recipient. We previously demonstrated that the acute intestinal GVHD (iGVHD) mortality rate was higher in MyD88-deficient BM recipients than that in the control BM recipients. In the present study, the role of MyD88 (expressed by donor BM) in the pathophysiology of hepatic GVHD (hGVHD) was examined. Unlike iGVHD, transplantation with MyD88- deficient T-cell depleted (TCD) BM attenuated hGVHD severity and was associated with low infiltration of T cells into the liver of the recipients. Moreover, GVHD hosts, transplanted with MyD88-deficient TCD BM, exhibited markedly reduced expansion of CD11b＋Gr-1＋ myeloidderived suppressor cells (MDSC) in the liver. Adoptive injection of the MDSC from wild type mice, but not MyD88-deficient mice, enhanced hepatic T cell infiltration in the MyD88-deficient TCD BM recipients. Pre-treatment of BM donors with LPS increased MDSC levels in the liver of allogeneic wild type BM recipients. In conclusion, hGVHD and iGVHD may occur through various mechanisms based on the presence of MyD88 in the non-T cell compartment of the allograft.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
[학술지(정기간행물)] - Hill, G. R. / 1997 / Total body irradiation acute graft-versus-host disease : the role of gastrointestinal damage inflammatory cytokines / Blood 90 : 3204 ~ 3213
[학술지(정기간행물)] - Caron, G. / 2005 / Direct stimulation of human T cells via TLR5 TLR7/8: flagellin R-848 up-regulate proliferation IFN-gamma production by memory CD4＋ T cells / J. Immunol 175 : 1551 ~ 1557
[학술지(정기간행물)] - Heimesaat, M. M. / 2010 / MyD88/TLR9mediated immunopathology gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease / Gut 59 : 1079 ~ 1087
[학술지(정기간행물)] - Quigley, M. / 2009 / A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion memory formation following vaccinia viral infection / Blood 113 : 2256 ~ 2264
[학술지(정기간행물)] - Rakoff-Nahoum, S. / 2004 / Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis / Cell 118 : 229 ~ 241
[학술지(정기간행물)] - Caron, G. / 2005 / Direct stimulation of human T cells via TLR5 TLR7/8: flagellin R-848 up-regulate proliferation IFN-gamma production by memory CD4＋ T cells / J. Immunol 175 : 1551 ~ 1557
[학술지(정기간행물)] - Heimesaat, M. M. / 2010 / MyD88/TLR9mediated immunopathology gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease / Gut 59 : 1079 ~ 1087
[학술지(정기간행물)] - Quigley, M. / 2009 / A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion memory formation following vaccinia viral infection / Blood 113 : 2256 ~ 2264
[학술지(정기간행물)] - Rakoff-Nahoum, S. / 2004 / Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis / Cell 118 : 229 ~ 241
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UCI(KEPA) : I410-ECN-0101-2016-511-001754653