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학술저널
저자정보
Yoon, Seo-Hyun (Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University) Park, Hae-Jeong (Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University) Zheng, Longtai (Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University) Hong, Mee-Suk (Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University) Kim, Jong-Woo (Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University) Yim, Sung-Vin (Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University) Chung, Joo-Ho (Kohwang Medical Research Institute, Department of Pharmacology, College of Medicine, Kyung Hee University)
저널정보
대한독성유전단백체학회 Molecular & cellular toxicology Molecular & cellular toxicology 제2권 제3호
발행연도
2006.1
수록면
212 - 215 (4page)

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Several reports have suggested a possible relationship between blood coagulation factors and schizophrenia. Plasminogen activator inhibitor type 1 (PAI-1) belongs to a serine protease inhibitor family, which regulates fibrinolysis and proteolysis by inhibiting plasminogen activation. The purpose of this study was to investigate the association of polymorphisms of the PAI-1 gene with schizophrenia in Korean population. Two important polymorphisms (-675 4G/5G and -844 G/A) located on promoter region of the PAI-1 gene were analyzed on 178 schizophrenia patients and 226 controls. The genotypic and allelic associations of -675 4G/5G were found significant. Furthermore, haplotype analysis revealed significant result, which suggests that -675 4G/5G polymorphism might confer increased susceptibility for schizophrenia in Korean population.

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