Association between a p73 Gene Polymorphism and Genetic Susceptibility to Non-small Cell Lung Cancer in the South of China

Wang, Shuang-Shuang; Guo, Hai-Yan; Dong, Lin-Li; Zhu, Xiang-Qian; Ma, Liang; Li, Wen; Tang, Jian-Xin

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자료유형: 학술저널

저자정보: Wang, Shuang-Shuang (Key Laboratory of Green Packaging and Application of Biological Nanotechnology, Hunan University of Technology) Guo, Hai-Yan (Department of Obstetrics and Gynecology, Xi'an No.4 Hospital) Dong, Lin-Li (Key Laboratory of Green Packaging and Application of Biological Nanotechnology, Hunan University of Technology) Zhu, Xiang-Qian (Hunan Provincial Tumor Hospital) Ma, Liang (Key Laboratory of Green Packaging and Application of Biological Nanotechnology, Hunan University of Technology) Li, Wen (Key Laboratory of Green Packaging and Application of Biological Nanotechnology, Hunan University of Technology) Tang, Jian-Xin (Key Laboratory of Green Packaging and Application of Biological Nanotechnology, Hunan University of Technology)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제23호

발행연도: 2014.1

수록면: 10,387 - 10,391 (5page)

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Background: This study aimed to identify any association between the p73 gene G4C14-to-A4T14 polymorphism and risk of non-small cell lung cancer (NSCLC) in the south of China. Materials and Methods: We genotyped the p73 gene polymorphism of peripheral blood DNA from 168 patients with NSCLC and 195 normal controls using HRM (high resolution melting) and PCR-CTPP (polymerase chain reaction with confronting two-pair primers). Results: The results of genotyping by HRM and PCR-CTPP were consistent with direct sequencing, the p73 genotype distribution in 168 lung cancer patients being as follows: GC/GC 101 cases (60.1%), GC/AT 59 cases (35.1%), AT/AT 8 cases (4.8%). The carriers of AT/AT genotype had a significantly reduced risk of NSCLC (OR=0.370; 95%CI: 0.170-0.806; p=0.010) as compared with non-carriers. However, we found no relations between p73 genotypes and histological type (p=0.798, $x^2=0.452$), tumor stage (p=0.806, $x^2=0.806$), or lymph node metastasis (p=0.578, $x^2=1.098$). Conclusions: Our findings suggest that the p73 G4C14-to-A4T14 polymorphism may be a modifier of NSCLC susceptibility in the Chinese population.

#NSCLC #p73 gene polymorphism #HRM and PCR-CTPP

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Wang, Shuang-Shuang

소속기관 Key Laboratory of Green Packaging and Application of Biological Nanotechnology of Hunan Province