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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 176 - 185 (10page)
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초록· 키워드
오류제보하기
Plasminogen activator inhibitor (PAI)-1 is a serine protease that, in addition to its major role in hemostasis, is known to play an essential role in tissue remodeling. Recent evidence indicates that chronic asthma may lead to tissue remodeling such as subepithelial fibrosis and extracellular matrix (ECM) deposition in the airways. However, the role of PAI-1 in asthma is unknown. Recently, we demonstrated that the mast cell (MC), which plays a major role in asthma, is a novel source of PAI-1 and a large number of MCs expressing PAI-1 are infiltrated in the airways of patients with asthma. Furthermore, PAI-1-deficient mice show
reduced ECM deposition in the airways of a murine model of asthma. In a human study, the 4G allele frequency of the PAI-1 gene was significantly higher in the asthmatic patients than in the control group. In view of the findings that the 4G allele is associated with elevated plasma PAI-1 level, elevated PAI-1 level in the lung may contribute to the development of asthma. In conclusion, PAI-1 may play an important role in the pathogenesis of asthma by promoting ECM deposition in the airways of asthmatics.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
/ / Goetzl EJ. Oxygenation products of arachinonic acid as mediators of hypersensitivity and inflammation. Med Clin North Am 1981 : 809 ~ 28
/ / Haahtela T. A comparative study of the effects of an inhaled corticosteroid on airway inflammation in newly diagnosed asthma : 32 ~ 42
/ / Holgate ST. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1989 : 520 ~ 4
/ / Hossain S. Hyperplasia of bronchial muscle in asthma. J Pathol 1973 : 319 ~ 31
/ / Hunninghake GW. Direct evidence of a role for mast cells in the pathogenesis of antigen induced bronchoconstriction. J Clin Invest 1987 : 1507 ~ 11
/ / Haahtela T. A comparative study of the effects of an inhaled corticosteroid on airway inflammation in newly diagnosed asthma : 32 ~ 42
/ / Holgate ST. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1989 : 520 ~ 4
/ / Hossain S. Hyperplasia of bronchial muscle in asthma. J Pathol 1973 : 319 ~ 31
/ / Hunninghake GW. Direct evidence of a role for mast cells in the pathogenesis of antigen induced bronchoconstriction. J Clin Invest 1987 : 1507 ~ 11
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