지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objective: The aim of the present study was to evaluate the clinical efficiency of fluorescent in situ hybridization (FISH) in the prenatal diagnosis of chromosomal aneuploidy. Methods: We reviewed data of 268 cases to identify women undergoing genetic amniocentesis at cytogenetic laboratory, from January 2000 to December 2002. Amniotic fluid was submitted for both rapid FISH on uncultured interphase amniocytes using a commercially available DNA probe for chromosome 13, 18, 21, X, Y and standard karyotyping on cultured metaphase amniocytes. Results from FISH and full karyotype were compared. Results: There were 251 cases (84%) normal and 17 cases (16%) abnormal in FISH results. All 17 cases of trisomy 13, 18, 21 including two cases of mosaicism and sex chromosome aneuploidies which are detected by FISH were confirmed with conventional cytogenetics and there was no false positive result. Twenty two cases had karyotypically proven abnormalities that could not have been detected by the targeted FISH. Conclusion: Interphase FISH analysis of uncultured amniotic fluid cells has been shown to be an effective and reliable technique for rapid fetal aneuploidy screening during pregnancy as an adjunctive test to conventional cytogenetics.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Rapid prenatal diagnosis of chromosome aneuploidies in 943 uncultured amniotic fluid samples by fluorescence in situ hybridization (FISH)
Journal of genetic medicine
2008 .01
-
Rapid detection of aneuploidy using FISH in uncultured amniocytes for prenatal diagnosis : 8-year experience
Journal of genetic medicine
2007 .01
-
FISH를 이용한 다운증후군과 에드워드증후군의 신속한 산전확인 : 309예의 임상적 고찰
Journal of genetic medicine
2007 .01
-
유전질환 및 염색체 이상의 예방을 위한 착상전 유전진단의 결과
대한불임학회지
2002 .01
-
An overview of current knowledge about cell-free RNA in amniotic fluid
Journal of genetic medicine
2016 .01
-
유전질환 진단에 있어서의 Fluorescence in Situ Hybridization (FISH)법의 임상적 유용성
Obstetrics & Gynecology Science
2002 .01
-
Down-Turner Syndrome (45,X/47,XY,+21): Case Report and Review
Annals of Laboratory Medicine
2010 .01
-
Validation of fetus aneuploidy in 221 Korean clinical samples using noninvasive chromosome examination: Clinical laboratory improvement amendments-certified noninvasive prenatal test
Journal of genetic medicine
2015 .01
-
국산 Fluorescence in Situ Hybridization 시스템을 이용한 다양한 검체에서의 염색체 분석
대한불임학회잡지
1997 .01
-
Korean physicians' attitudes toward the prenatal screening for fetal aneuploidy and implementation of non-invasive prenatal testing with cell-free fetal DNA
Journal of genetic medicine
2018 .01
-
Noninvasive prenatal test for fetal chromosomal aneuploidies by massively parallel sequencing of cell-free fetal DNA in maternal plasma: The first clinical experience in Korea
Journal of genetic medicine
2015 .01
-
Variant Philadelphia Chromosome Identified by Interphase Fluorescence In Situ Hybridization (FISH) without Evidence on G-banded Karyotyping and Metaphase FISH
Annals of Laboratory Medicine
2010 .01
-
Effects of Maternal Age and Embryo Quality on the Aneuploidy of Embryos from Translocation Carriers in PGD-FISH Cycles
대한생식의학회 학술대회
2005 .01
-
FISH를 이용한 정자의 염색체 분석
대한생식의학회 연수강좌
2001 .01
-
형광 동소 보합법을 이용한 췌장암의 세포유전학적 변화에 대한 분석과 그 임상적 의의
Annals of Hepato-Biliary-Pancreatic Surgery
2008 .03
-
Application of digital polymerase chain reaction technology for noninvasive prenatal test
Journal of genetic medicine
2015 .01
-
Efficacy of fetal cardiac axis evaluation in the first trimester as a screening tool for congenital heart defect or aneuploidy
Obstetrics & Gynecology Science
2020 .01
-
Quantitative fluorescent polymerase chain reaction for rapid prenatal diagnosis of fetal aneuploidies in chorionic villus sampling in a single institution
Obstetrics & Gynecology Science
2016 .01
-
Combined Study of Cytogenetics and Fluorescence in Situ Hybridization (FISH) Analysis in Childhood Acute Lymphoblastic Leukemia (ALL) in a Tertiary Cancer Centre in South India
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Fish consumption advisory for mercury in Korean freshwater fish
환경독성보건학회 심포지엄 및 학술대회
2011 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0