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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Objectives : Schizophrenia is a clinically heterogenous disease with a strong genetic component. Many studies have suggested that brain-derived neurotrophic factor(BDNF) is involved in the pathophysiology of schizophrenia. This study was performed to determine whether there is an association between BDNF Val66Met polymorphism and schizophrenia. Methods : To identify any genetic predisposition to schizophrenia, we investigated the BDNF Val66Met polymorphism in 106 patients with schizophrenia and 147 normal controls with PCR-RFLP method. Statistical analyses were used to test the association between and BDNF Val66Met genotype and Schizophrenia. Results : No association was found between BDNF Val66Met polymorphism and schizophrenia. No significant differences were found comparing the BDNF genotype distributions according to the age of onset, the number of admission and familial loading in schizophrenia. Conclusion : This result indicates that BDNF Val66Met polymorphism is not associated with schizophrenia. However, further studies with a large number of subjects are needed to confirm whether the BDNF gene is related to schizophrenia.
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Effect of the Presence of Brain-Derived Neurotrophic Factor Val66Met Polymorphism on the Recovery in Patients With Acute Subcortical Stroke
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Brain-Derived Neurotrophic Factor(BNDF) Val66Met 유전자 다형성과 성격 특성에 대한 연합연구
생물정신의학
2005 .01
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지연성 운동장애와 BDNF(Brain-derived Neurotrophic Factor) Val66Met 유전자 다형성과의 연관성연구
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2006 .06
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Association between the BDNF Val66Met Polymorphism and Chronicity of Depression
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Genetic Role of BDNF Val66Met and 5-HTTLPR Polymorphisms on Depressive Disorder
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Effects of Mind-Body Training on Personality and Behavioral Activation and Inhibition System According to BDNF Val66Met Polymorphism
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Brain-derived Neurotrophic Factor Is Associated with Cognitive Impairment in Elderly Korean Individuals
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Gender-specific Associations of the Brain-derived Neurotrophic Factor Val66Met Polymorphism with Neurocognitive and Clinical Features in Schizophrenia
Clinical Psychopharmacology and Neuroscience
2016 .01
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Impact of the BDNF Val66Met Polymorphism on Regional Brain Gray Matter Volumes: Relevance to the Stress Response
PSYCHIATRY INVESTIGATION
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Prediction of Chemotherapy-Induced Peripheral Neuropathy in Patients with Lymphoma and Myeloma: the Roles of Brain-Derived Neurotropic Factor Protein Levels and A Gene Polymorphism
Journal of Clinical Neurology
2019 .01
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The rs6265 Polymorphism of the BDNF Gene Is Related to Higher-Lethality Suicide Attempts in the Korean Population
PSYCHIATRY INVESTIGATION
2020 .01
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한국인 우울 장애 환자에서 Brain-Derived Neurotrophic Factor(BDNF)의 유전자 다형성과 항우울제의 장기 치료 반응
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Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism Is a Risk Factor for Attention-Deficit Hyperactivity Disorder in a Turkish Sample
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Effects of BDNF Polymorphisms on Antidepressant Action
PSYCHIATRY INVESTIGATION
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정신분열병 환자의 혈청에서 Brain-Derived Neurotrophic Factor 증가
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A Review of Brain-derived Neurotrophic Factor as a Candidate Biomarker in Schizophrenia
Clinical Psychopharmacology and Neuroscience
2012 .01
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우울증 환자의 혈액에서 측정되는 BDNF 농도 변화와 그 의미
신경정신의학
2009 .01
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20대 한국 직장인의 음주 심각도에 대한 직무 스트레스와 BDNF 유전자 다형성의 역할
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2012 .01
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No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia
PSYCHIATRY INVESTIGATION
2009 .01
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