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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 311 - 319 (9page)
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초록· 키워드
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Objective To investigate the effect of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on the recovery after subcortical stroke, using the modified Rankin Scale (mRS).Methods Subcortical stroke patients with copies of BDNF Val66Met polymorphism (n=7) were compared to their controls (n=7) without a copy of BDNF Val66Met polymorphism after matching for initial severity, location and type of stroke. The mRS scores at 1 and 3 months after discharge from the neurorehabilitation unit were compared between the groups.Results A repeated measures ANOVA for mRS revealed significant interaction between time and group (F(2, 24) =37.2, p<0.001) and a significant effect of time (F(2, 24)=10.8, p<0.001), thereby reflecting significant differences between the Met allele (+) group and the Met allele (-) group. There was a significant difference in mRS scores at 3 months post-discharge between the two groups (p=0.01) although no difference was evident in mRS scores at 1 month post-discharge between the two groups. There were significant improvements between mRS scores on admission and mRS scores at 1 month post-discharge (p=0.02), and between mRS scores at 1 month post-discharge and mRS scores at 3 months post-discharge (p=0.004) in the Met allele (-) group.Conclusion BDNF Val66Met polymorphism may be associated with worse functional outcome in Korean patients with subcortical stroke. Therefore, BDNF Val66Met polymorphism should be considered as an important prognostic factor for recovery and responses to rehabilitation therapies after stroke in Korean patients. There is a need for developing different rehabilitation strategies for the population with BDNF Val66Met polymorphism. Further studies assessing different outcomes for various functional domains of stroke recovery are needed to clarify the role of BDNF Val66Met polymorphism.
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참고문헌 (23)
참고문헌 신청
Bonita R. / 2004 / The global stroke initiative / Lancet Neurol 3 : 391 ~ 393
Bosnell RA. / 2011 / Motor practice promotes increased activity in brain regions structurally di
Chen CL. / 2000 / Brain lesion size and location : effects on motor recovery and functional outcome in stroke patients / Arch Phys Med Rehabil 81 : 447 ~ 452
Cramer SC. / 2012 / Correlation between genetic polymorphisms and stroke recovery : analysis of the GAIN Americas and GAIN International Studies / Eur J Neurol 19 : 718 ~ 724
Dimou L. / 2008 / Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex / J Neurosci 28 : 10434 ~ 10442
Bosnell RA. / 2011 / Motor practice promotes increased activity in brain regions structurally di
Chen CL. / 2000 / Brain lesion size and location : effects on motor recovery and functional outcome in stroke patients / Arch Phys Med Rehabil 81 : 447 ~ 452
Cramer SC. / 2012 / Correlation between genetic polymorphisms and stroke recovery : analysis of the GAIN Americas and GAIN International Studies / Eur J Neurol 19 : 718 ~ 724
Dimou L. / 2008 / Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex / J Neurosci 28 : 10434 ~ 10442
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