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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 511 - 516 (6page)
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초록· 키워드
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Background and Purpose Brain-derived neurotrophic factor (BDNF) is a neuronal growth factor that plays an essential role in the maintenance of the nervous system. We have evaluated the peripheral blood protein levels of BDNF and the valine-to-methionine substitution at codon 66 (Val66Met) single-nucleotide polymorphism (SNP) as potential biomarkers for the early recognition of chemotherapy-induced peripheral neuropathy (CIPN) in non-Hodgkin lymphoma and multiple myeloma patients. Methods CIPN was assessed in 45 patients at the diagnosis and during vincristine or bortezomib-based therapy using objective [reduced version of the Total Neuropathy Score (TNSr)] and subjective (FACT-GOG-NTx) tools. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9) questionnaire. BDNF protein levels and the Val66Met SNP were determined using ELISA and Sanger sequencing. Results Te pretreatment BDNF protein level was inversely correlated with the maximum TNSr, FACT-GOG-NTx, and PHQ-9 scores in both genotypes. BDNF patients with the Val/Val genotype demonstrated signifcantly higher maximum FACT-GOG-NTx and PHQ-9 scores than those with the Val/Met and Met/Met genotypes (Met-BNDF carriers). Correlations between PHQ-9 and TNSr score were found only in Met-BDNF carriers, suggesting that peripheral neuropathy and depression coincide in Met-BDNF carriers. Conclusions Determining the BDNF protein levels before initiating chemotherapy might be a useful tool for CIPN risk assessment and preemptive dose modifcation. Te present data should be validated in larger studies that include other neurotoxic agents.
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참고문헌 (15)
참고문헌 신청
Seretny M / 2014 / Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy : a systematic review and meta-analysis / Pain 155:2461~2470
Verstappen CC / 2003 / Neurotoxic complications of chemotherapy in patients with cancer : clinical signs and optimal management / Drugs 63:1549~1563
Cavaletti G / 2004 / Early predictors of peripheral neurotoxicity in cisplatin and paclitaxel combination chemotherapy / Ann Oncol 15:1439~1442
Andreassen CS / 2009 / Expression of neurotrophic factors in diabetic muscle--relation to neuropathy and muscle strength / Brain 132:2724~2733
Azoulay D / 2015 / Association between Met-BDNF allele and vulnerability to paclitaxel-induced peripheral neuropathy / Breast Cancer Res Treat 153:703~704
Verstappen CC / 2003 / Neurotoxic complications of chemotherapy in patients with cancer : clinical signs and optimal management / Drugs 63:1549~1563
Cavaletti G / 2004 / Early predictors of peripheral neurotoxicity in cisplatin and paclitaxel combination chemotherapy / Ann Oncol 15:1439~1442
Andreassen CS / 2009 / Expression of neurotrophic factors in diabetic muscle--relation to neuropathy and muscle strength / Brain 132:2724~2733
Azoulay D / 2015 / Association between Met-BDNF allele and vulnerability to paclitaxel-induced peripheral neuropathy / Breast Cancer Res Treat 153:703~704
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