지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 239 - 247 (9page)
이용수
초록· 키워드
오류제보하기
Objectives: Allium jesdianum (Aj) is a medicinal plant that has highlighted pharmacological features. In this study, the effects of Aj extract were examined on acetaminophen (APAP)-induced hepatic failure in rats. Methods: Methanolic fraction of hydro-alcoholic extract of Aj was obtained by silica gel column chromatography method. Animals were randomly divided into four groups each containing six rats and treated by gavage as follows: the first and second groups received normal saline, the third and fourth groups were received with 50 and 100 mg/kg of Aj extract, respectively. After two consecutive weeks, the groups 2-4 were given a single dose of APAP (2 g/kg). After 48 hours, blood and liver samples were collected for biochemical and histological examinations. Results: The findings of the study demonstrated that APAP caused a significant increase in ALT (P < 0.001), AST (P < 0.001), LDH (P < 0.001), ALP (P < 0.001) serum levels, hepatic lipid peroxidation (LPO; P < 0.001) and nitric oxide (NO; P < 0.001). In this regard, APAP led to the depletion of the total antioxidant capacity (TAC; P < 0.001), glutathione and total thiol groups (TTGs; P < 0.001), and structural change in the liver. In the Aj extract groups, a considerable improvement was found in the hepatic function alongside the histopathologic changes. Conclusion: This investigation indicated that the influential effects of Aj extract in APAP-induced hepatic failure might depend on its effect on improving oxidant/antioxidant balance in hepatic tissue.
목차
등록된 정보가 없습니다.
참고문헌 (52)
참고문헌 신청
Yoon E / 2016 / Acetaminophen-induced hepatotoxicity : a comprehensive update / J Clin Transl Hepatol 4(2):131~142
Abiko Y / 2015 / Formation of sulfur adducts of N-acetyl-p-benzoquinoneimine, an electrophilic metabolite of acetaminophen in vivo : participation of reactive persulfides / Chem Res Toxicol 28(9):1796~1802
Walker V / 2017 / The acetaminophen metabolite N-acetyl-p-benzoquinone imine(NAPQI)inhibits glutathione synthetase in vitro; a clue to the mechanism of 5-oxoprolinuric acidosis / Xenobiotica 47(2):164~175
Nili-Ahmadabadi A / 2019 / The occurrence of acetaminophen/ codeine as an adulterant in herbal analgesic supplements in Hamadan, Iran : A pilot study / Complement Ther Med 42:223~225
Karimi A / 2015 / Herbal versus synthetic drugs; beliefs and facts / J Nephropharmacol 4(1):27~30
Abiko Y / 2015 / Formation of sulfur adducts of N-acetyl-p-benzoquinoneimine, an electrophilic metabolite of acetaminophen in vivo : participation of reactive persulfides / Chem Res Toxicol 28(9):1796~1802
Walker V / 2017 / The acetaminophen metabolite N-acetyl-p-benzoquinone imine(NAPQI)inhibits glutathione synthetase in vitro; a clue to the mechanism of 5-oxoprolinuric acidosis / Xenobiotica 47(2):164~175
Nili-Ahmadabadi A / 2019 / The occurrence of acetaminophen/ codeine as an adulterant in herbal analgesic supplements in Hamadan, Iran : A pilot study / Complement Ther Med 42:223~225
Karimi A / 2015 / Herbal versus synthetic drugs; beliefs and facts / J Nephropharmacol 4(1):27~30
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice
The Korean Journal of Physiology & Pharmacology
2016 .01
-
Ginsenoside Rk1 ameliorates paracetamol-induced hepatotoxicity in mice through inhibition of inflammation, oxidative stress, nitrative stress and apoptosis
Journal of Ginseng Research
2019 .01
-
응급의료센터에서 아세트아미노펜 과다복용 환자의 검사실 분석 현황: 일개 중독분석실 농도 분석자료 포함
대한임상독성학회지
2021 .01
-
창출이 제 2형 당뇨병 흰쥐에 미치는 영향
대한한의학회지
2015 .03
-
Effects of Albizia julibrissin Durazz through Suppression of Mitochondrial Fission and Apoptosis in Cisplatin-induced Acute Kidney Injury
Natural Product Sciences
2022 .12
-
금속매염제인 초산구리의 세포독성에 대한 자귀나무잎 추출물의 보호 효과
한국환경보건학회지
2019 .01
-
폐쇄성 수면 무호흡증후군 환자에서 자동형 양압 호흡기치료의 순응도 예측인자 분석
Journal of Rhinology
2015 .01
-
Detection of acetaminophen-induced liver damage by fluorescence bioimaging, serum biochemistry and histopathological examination
Journal of Biomedical and Translational Research
2020 .01
-
Alternative serum chemistry biomarkers of acetaminopheninduced liver injury in rats
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Intentional Death Caused by the Overdose of Nonprescription Drugs: An Autopsy Case of Acetaminophen Poisoning
대한법의학회지
2020 .01
-
Percutaneous transhepatic hepatic venous stenting after extracorporeal hepatic resection and autotransplantation: A case report
International Journal of Gastrointestinal Intervention
2017 .10
-
Hepatic Vascular Intervention
대한인터벤션영상기술학회지
2018 .05
-
Comparison of the Antioxidant Activities of Various Processed Fruits and Vegetables in APAP-induced Oxidative Stress in BALB/c Mice
대한의생명과학회지
2019 .09
-
Albizzia julibrissin Suppresses Testosterone-induced Benign Prostatic Hyperplasia by Regulating 5α-Reductase Type 2 - Androgen Receptor Pathway
Natural Product Sciences
2019 .09
-
Evaluation and Management of Hepatic Encephalopathy: Current Status and Future Directions
Gut and Liver
2016 .01
-
Risk factors of postoperative ascites on hepatic resection for hepatocellular carcinoma
Annals of Hepato-Biliary-Pancreatic Surgery
2016 .11
-
Changes in the types of liver diseases requiring hepatic resection : A single-institution experience of 9016 cases over a 10-year period
한국간담췌외과학회 학술대회지
2016 .04
-
Fatal neurological complication after liver transplantation in acute hepatic failure patient with hepatic encephalopathy
고신대학교 의과대학 학술지
2018 .01
-
Paradigm Shift in Hepatic Injury
대한외과학회 학술대회 초록집
2020 .11
-
Factors Affecting Automatic Positive Airway Pressure Therapy Adherence in Patients Who had Completed the 3-Month Compliance Assessment for Korean National Health Insurance Coverage
sleep medicine research
2021 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0