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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 520 - 528 (9page)
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Objectives: This study assessed the cytotoxicity of the metallic mordant cupric acetate (CA) and the protective effect of Albizzia julibrissin (AJ) leaf extract on CA-induced cytotoxicity in NIH3T3 fibroblasts. Methods: For this study, cell viability and antioxidative effects such as the inhibitory activity of lipid peroxidation (LP) and superoxide anion-radical (SAR) scavenging activity were assessed. Results: CA significantly decreased cell viability in a dose-dependent manner, and the XTT50 value was measured as 55.0 µM of CA. The cytotoxicity of CA was determined as highly toxic by Borenfreund and Puerner’s toxic criteria. The catalase antioxidant significantly increased cell viability diminished by CA-induced cytotoxicity in these cultures. Regarding the protective effect of AJ leaf extract on CA-induced cytotoxicity, AJ leaf extract remarkably increased the SAR scavenging ability and the inhibitory ability of LP. From these findings, it is suggested that oxidative stress is involved in the cytotoxicity of CA, and AJ leaf extract effectively protected CA-induced cytotoxicity via antioxidative effects. Conclusions: Natural resources like AJ leaf extract may be a putative therapeutic agent for treatment or alleviation of the toxicity induced by CA metallic mordant.
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참고문헌 (32)
참고문헌 신청
김성천 / 2011 / 공업도시의 금속원소 조사와 특성 연구 / 한국환경보건학회지 37(3):209~217
Cho KS / 1991 / Occupational health / Sumoonsa Academic Publishing :449
조태진 / 2010 / 일반대기 중 극미세입자와 중금속 농도에 관한 연구 / 한국환경보건학회지 36(6):480~495
Sandstead HH / 1995 / Requirements and toxicity of essential trace elements illustrated by zink and copper / American Journal of Clinical Nutrition 61(3):621~624
Batista BL / 2008 / Simultaneous determination of Cd, Cu, Mn, Ni, Pb and Zn in nail samples by inductively coupled plasma mass spectrometry (ICP-MS) after tetramethylammonium hydroxide solubilization at room temperature: comparison with ETAAS / Talanta 76(3):575~579
Cho KS / 1991 / Occupational health / Sumoonsa Academic Publishing :449
조태진 / 2010 / 일반대기 중 극미세입자와 중금속 농도에 관한 연구 / 한국환경보건학회지 36(6):480~495
Sandstead HH / 1995 / Requirements and toxicity of essential trace elements illustrated by zink and copper / American Journal of Clinical Nutrition 61(3):621~624
Batista BL / 2008 / Simultaneous determination of Cd, Cu, Mn, Ni, Pb and Zn in nail samples by inductively coupled plasma mass spectrometry (ICP-MS) after tetramethylammonium hydroxide solubilization at room temperature: comparison with ETAAS / Talanta 76(3):575~579
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