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Objectives: Type 2 diabetes mellitus is a metabolic disease characterized by insulin resistance and high blood glucose level from progressive insulin secretory defect. The rhizome of Atractylodes japonica Koidz. (AJ) has been used for treatment of retention of water in oriental medicine. The aim of this study is to examine the effects of AJ on type 2 diabetes rats.
Methods: Type 2 diabetes was induced by 60% high fat diet and low dose streptozotocin. Rats were divided into 4 groups (n = 6); Nor (normal control group), Con (diabetic group treated with vehicle), Met (diabetic group treated with 200 ㎎/㎏ metformin) and AJ (diabetic group treated with 100 ㎎/㎏ AJ). The body weights and food intakes were measured during the treatment period. After 4 weeks treatment, blood glucose level, HOMA-IR, and protein expressions of IRS-1, p-IRS-1, PPAR-γ, and GLUT4 were measured, and histopathological examination of beta cell was performed.
Results: Compared with the control group, blood glucose level and HOMA-IR were reduced in rats treated with AJ. Impaired beta cells in pancreas of rats were recovered and phosphorylation of IRS-1 was increased in rats treated with AJ. And also, protein expressions of PPAR-γ and GLUT4 were increased by treatment of AJ.
Conclusions: The results suggest that Atractylodes japonica Koidz. may have anti-diabetic effect on type 2 diabetic rats through regulation of blood glucose level and insulin resistance. Therefore Atractylodes japonica Koidz. may have positive effects on patients with type 2 diabetes.
Methods: Type 2 diabetes was induced by 60% high fat diet and low dose streptozotocin. Rats were divided into 4 groups (n = 6); Nor (normal control group), Con (diabetic group treated with vehicle), Met (diabetic group treated with 200 ㎎/㎏ metformin) and AJ (diabetic group treated with 100 ㎎/㎏ AJ). The body weights and food intakes were measured during the treatment period. After 4 weeks treatment, blood glucose level, HOMA-IR, and protein expressions of IRS-1, p-IRS-1, PPAR-γ, and GLUT4 were measured, and histopathological examination of beta cell was performed.
Results: Compared with the control group, blood glucose level and HOMA-IR were reduced in rats treated with AJ. Impaired beta cells in pancreas of rats were recovered and phosphorylation of IRS-1 was increased in rats treated with AJ. And also, protein expressions of PPAR-γ and GLUT4 were increased by treatment of AJ.
Conclusions: The results suggest that Atractylodes japonica Koidz. may have anti-diabetic effect on type 2 diabetic rats through regulation of blood glucose level and insulin resistance. Therefore Atractylodes japonica Koidz. may have positive effects on patients with type 2 diabetes.
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실험방법
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고찰
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참고문헌
참고문헌 (36)
참고문헌 신청
1. [학술지(정기간행물)] - Mccarthy MI / 2010 / Genomics, type 2 diabetes, and obesity / The New England Journal of Medicine 363 (24) : 2339 ~ 2350
2. [학술지(정기간행물)] - Kahn SE / 2006 / Mechanisms linking obesity to insulin resistance and type 2 diabetes / Nature 444 (7121) : 840 ~ 846
3. [기타자료] - Korean diabetes association / / Diabetes fact sheet in korea 2012
4. [학술지(정기간행물)] - Alberti KGMM / 1998 / Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation / Diabetic medicine: a journal of the British Diabetic Association 15 (7) : 539 ~ 553
5. [학술지(정기간행물)] - American diabetes association / 2014 / Standards of medical care in diabetes-2014 / Diabetes Care 37 (1) : S14 ~ S80
2. [학술지(정기간행물)] - Kahn SE / 2006 / Mechanisms linking obesity to insulin resistance and type 2 diabetes / Nature 444 (7121) : 840 ~ 846
3. [기타자료] - Korean diabetes association / / Diabetes fact sheet in korea 2012
4. [학술지(정기간행물)] - Alberti KGMM / 1998 / Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation / Diabetic medicine: a journal of the British Diabetic Association 15 (7) : 539 ~ 553
5. [학술지(정기간행물)] - American diabetes association / 2014 / Standards of medical care in diabetes-2014 / Diabetes Care 37 (1) : S14 ~ S80
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UCI(KEPA) : I410-ECN-0101-2016-519-001392175