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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 417 - 424 (8page)
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The purpose of this study was to observe the effects of the polysaccharide (GLP) obtained from the liquid cultured Ganoderma lucidum on the lipidperoxidation in a rat liver microsome and hepatotoxicity in the primary cultured rat hepatocytes. It is well known that the polysaccharide of Ganoderma lucidum exhibits hepatoprotective activity, antitumor activity etc., which many suggest a relationship to lipidperoxidation. The effect of GLP on CCl4- and galactosamineintoxicated cytotoxicity in the primary cultured rat hepatocytes were reduced the GPT value. In order to the estimate the effects of anti-lipidperoxidation of the polysaccharide, enzymatic and nonenzymatic reaction assays were performed, in vitro, in the rat liver microsome. An enzymatic lipidperoxidation reaction by ADP＋FeCl3＋NADPH and CCl4＋NADPH, GLP (1 mg/mL) inhibited 77.4% and 39.4%, respectively, and the nonenzymatic reaction displayed a 97.4% strongly inhibition. In the enzymatic and nonenzymatic inducers treated with GLP, the formation of malondialdehyde (MDA) progressively decreased by raising the GLP concentration. These results suggest that the anti-lipidperoxidation and radical scavenging activity of GLP may play an important part in the liver protection action.
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참고문헌 (29)
참고문헌 신청
Albano E / 1982 / Spin-trapping studies on the free-radical products formed by metabolic activation of carbon tetrachloride in rat liver microsomal fractions isolated hepatocytes and in vivo in the rat / Biochem J 204:593~603
Chang SS / 2012 / Effect of Ganoderma lucidum polysaccharides on oxidative stress of hyperlipidemic fatty liver in rats / Zhongguo Zhongyao Zazhi 37:3102~3106
Comporti M / 1993 / Free Radicals: From Basic Science to Medicine / Birkhauser Verlag :65~79
하영래 / 2010 / 표고버섯균사체의 사염화탄소 및 알콜로 처리된 흰쥐 간기능 보호 효과 / 생명과학회지 20(1):133~141
Halliwell B / 1987 / The deoxyribose method: A simple "test-tube" assay for determination of rate constants for reactions of hydroxyl radicals / Anal Biochem 165:215~219
Chang SS / 2012 / Effect of Ganoderma lucidum polysaccharides on oxidative stress of hyperlipidemic fatty liver in rats / Zhongguo Zhongyao Zazhi 37:3102~3106
Comporti M / 1993 / Free Radicals: From Basic Science to Medicine / Birkhauser Verlag :65~79
하영래 / 2010 / 표고버섯균사체의 사염화탄소 및 알콜로 처리된 흰쥐 간기능 보호 효과 / 생명과학회지 20(1):133~141
Halliwell B / 1987 / The deoxyribose method: A simple "test-tube" assay for determination of rate constants for reactions of hydroxyl radicals / Anal Biochem 165:215~219
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