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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제20권 제6호
- 발행연도
- 2016.11
- 수록면
- 613 - 619 (7page)
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초록· 키워드
오류제보하기
Diabetic cardiomyopathy (DCM), a serious complication of diabetes mellitus, is associated with changes in myocardial structure and function. This study sought to explore the ability of insulin-like growth factor-1 (IGF-1) to modulate DCM and its related mechanisms. Twenty-four male Wistar rats were injected with streptozotocin (STZ, 60 mg/kg) to mimic diabetes mellitus. Myocardial fibrosis and apoptosis were evaluated by histopathologic analyses, and relevant proteins were analyzed by Western blotting. Inflammatory factors were assessed by ELISA. Markers of oxidative stress were tested by colorimetric analysis. Rats with DCM displayed decreased body weight, metabolic abnormalities, elevated apoptosis (as assessed by the bcl-2/bax ratio and TUNEL assays), increased fibrosis, increased markers of oxidative stress (MDA and SOD) and inflammatory factors (TNF-α and IL-1β), and decreased phosphorylation of Akt and glycogen synthase kinase (GSK-3β). IGF- 1 treatment, however, attenuated the metabolic abnormalities and myocardial apoptosis, interstitial fibrosis, oxidative stress and inflammation seen in diabetic rats, while also increasing the phosphorylation levels of Akt and GSK-3β. These findings suggest that IGF-1 ameliorates the pathophysiological progress of DCM along with an activation of the Akt/GSK-3β signaling pathway. Our findings suggest that IGF-1 could be a potential therapeutic choice for controlling DCM.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Kitabchi AE / 2009 / Hyperglycemic crises in adult patients with diabetes / Diabetes Care 32:1335~1343
Huynh K / 2010 / Cardiac-specific IGF-1 receptor transgenic expression protects against cardiac fibrosis and diastolic dysfunction in a mouse model of diabetic cardiomyopathy / Diabetes 59:1512~1520
Jiang LH / 2015 / Daucosterol protects neurons against oxygen-glucose deprivation/reperfusion-mediated injury by activating IGF1 signaling pathway / J Steroid Biochem Mol Biol 152:45~52
Setshedi M / 2011 / Limited therapeutic effect of N-acetylcysteine on hepatic insulin resistance in an experimental model of alcoholinduced steatohepatitis / Alcohol Clin Exp Res 35:2139~2151
Shen Y / 2015 / Pathways involved in interleukin-1betamediated murine cardiomyocyte apoptosis / Tex Heart Inst J 42:109~116
Huynh K / 2010 / Cardiac-specific IGF-1 receptor transgenic expression protects against cardiac fibrosis and diastolic dysfunction in a mouse model of diabetic cardiomyopathy / Diabetes 59:1512~1520
Jiang LH / 2015 / Daucosterol protects neurons against oxygen-glucose deprivation/reperfusion-mediated injury by activating IGF1 signaling pathway / J Steroid Biochem Mol Biol 152:45~52
Setshedi M / 2011 / Limited therapeutic effect of N-acetylcysteine on hepatic insulin resistance in an experimental model of alcoholinduced steatohepatitis / Alcohol Clin Exp Res 35:2139~2151
Shen Y / 2015 / Pathways involved in interleukin-1betamediated murine cardiomyocyte apoptosis / Tex Heart Inst J 42:109~116
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