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TGF-β signaling plays a tumor suppressive role in normal and premalignant cells but promotes tumor progression during the late stages of tumor development. The TGF-β signaling pathway is tightly regulated at various levels, including transcriptional and post-translational mechanisms. Ubiquitination of signaling components, such as receptors and Smad proteins is one of the key regulatory mechanisms of TGF-β signaling. Tripartite motif (TRIM) family of proteins is a highly conserved group of E3 ubiquitin ligase proteins that have been implicated in a variety of cellular functions, including cell growth, differentiation, immune response, and carcinogenesis. Recent emerging studies have shown that some TRIM family proteins function as important regulators in tumor initiation and progression. This review summarizes current knowledge of TRIM family proteins regulating the TGF-β signaling pathway with relevance to cancer. (J Cancer Prev 2018;23:162-169)
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참고문헌 (79)
참고문헌 신청
Massagué J / 2012 / TGFβ signalling in context / Nat Rev Mol Cell Biol 13:616~630
Massagué J / 2000 / TGFbeta signaling in growth control, cancer, and heritable disorders / Cell 103:295~309
de Caestecker MP / 2000 / Role of transforming growth factor-beta signaling in cancer / J Natl Cancer Inst 92:1388~1402
Principe DR / 2014 / TGF-β: duality of function between tumor prevention and carcinogenesis / J Natl Cancer Inst 106:djt369
Katsuno Y / 2013 / TGF-β signaling and epithelial-mesenchymal transition in cancer progression / Curr Opin Oncol 25:76~84
Massagué J / 2000 / TGFbeta signaling in growth control, cancer, and heritable disorders / Cell 103:295~309
de Caestecker MP / 2000 / Role of transforming growth factor-beta signaling in cancer / J Natl Cancer Inst 92:1388~1402
Principe DR / 2014 / TGF-β: duality of function between tumor prevention and carcinogenesis / J Natl Cancer Inst 106:djt369
Katsuno Y / 2013 / TGF-β signaling and epithelial-mesenchymal transition in cancer progression / Curr Opin Oncol 25:76~84
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