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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 114 - 120 (7page)
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초록· 키워드
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rosophila hematopoiesis is comparable to mammalian differentiation of myeloid lineages, and therefore, has been a useful model organism in illustrating the molecular and genetic basis for hematopoiesis. Multiple novel regulators and signals have been uncovered using the tools of Drosophila genetics. A Runt domain protein, lozenge, is one of the first players recognized and closely studied in the hematopoietic lineage specification. Here, we explore the role of lozenge in determination of prohemocytes into a special class of hemocyte, namely the crystal cell, and discuss molecules and signals controlling the lozenge function and its implication in immunity and stress response. Given the highly conserved nature of Runt domain in both invertebrates and vertebrates, studies in Drosophila will enlighten our perspectives on Runx-mediated development and pathologies.
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등록된 정보가 없습니다.
참고문헌 (95)
참고문헌 신청
Agaisse, H. / 2003 / Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury / Dev. Cell 5:441~450
Anderson, R. C / 1945 / A study of the factors affecting fertility of lozenge females of Drosophila melanogaster / Genetics 30:280~296
Ashburner, M. / 1976 / Genetics and Biology of Drosophila / Academic Press
Bangs, P. / 2000 / Molecular mechanisms of cell death and phagocytosis in Drosophila / Cell Death Differ 7:1027~1034
Bataille, L. / 2005 / Resolving embryonic blood cell fate choice in Drosophila: interplay of GCM and RUNX factors / Development (Cambridge, England) 132:4635~4644
Anderson, R. C / 1945 / A study of the factors affecting fertility of lozenge females of Drosophila melanogaster / Genetics 30:280~296
Ashburner, M. / 1976 / Genetics and Biology of Drosophila / Academic Press
Bangs, P. / 2000 / Molecular mechanisms of cell death and phagocytosis in Drosophila / Cell Death Differ 7:1027~1034
Bataille, L. / 2005 / Resolving embryonic blood cell fate choice in Drosophila: interplay of GCM and RUNX factors / Development (Cambridge, England) 132:4635~4644
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