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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 104 - 112 (9page)
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Tracking the fate of individual cells and their progeny through lineage tracing has been widely used to investigate various biological processes including embryonic development, homeostatic tissue turnover, and stem cell function in regeneration and disease. Conventional lineage tracing involves the marking of cells either with dyes or nucleoside analogues or genetic marking with fluorescent and/or colorimetric protein reporters. Both are imaging-based approaches that have played a crucial role in the field of developmental biology as well as adult stem cell biology. However, imaging-based lineage tracing approaches are limited by their scalability and the lack of molecular information underlying fate transitions. Recently, computational biology approaches have been combined with diverse tracing methods to overcome these limitations and so provide high-order scalability and a wealth of molecular information. In this review, we will introduce such novel computational methods, starting from single-cell RNA sequencing-based lineage analysis to DNA barcoding or genetic scar analysis. These novel approaches are complementary to conventional imaging-based approaches and enable us to study the lineage relationships of numerous cell types during vertebrate, and in particular human, development and disease.
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참고문헌 (74)
참고문헌 신청
Alemany, A. / 2018 / Whole-organism clone tracing using singlecell sequencing / Nature 556:108~112
Alieva, M. / 2014 / Imaging windows for long-term intravital imaging : general overview and technical insights / IntraVital 3:e29917
Arnold, S. J. / 2009 / Making a commitment : cell lineage allocation and axis patterning in the early mouse embryo / Nat. Rev. Mol. Cell Biol 10:91~103
Bae, T. / 2018 / Different mutational rates and mechanisms in human cells at pregastrulation and neurogenesis / Science 359:550~555
Baran-Gale, J. / 2018 / Experimental design for single-cell RNA sequencing / Brief. Funct. Genomics 17:233~239
Alieva, M. / 2014 / Imaging windows for long-term intravital imaging : general overview and technical insights / IntraVital 3:e29917
Arnold, S. J. / 2009 / Making a commitment : cell lineage allocation and axis patterning in the early mouse embryo / Nat. Rev. Mol. Cell Biol 10:91~103
Bae, T. / 2018 / Different mutational rates and mechanisms in human cells at pregastrulation and neurogenesis / Science 359:550~555
Baran-Gale, J. / 2018 / Experimental design for single-cell RNA sequencing / Brief. Funct. Genomics 17:233~239
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