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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.3
- 수록면
- 503 - 513 (11page)
- DOI
- 10.7465/jkdi.2019.30.2.503
이용수
초록· 키워드
오류제보하기
The genomic basis of adaptation to novel environments is a fundamental problem in evolutionary biology that has gained additional importance in the light of the recent discussion about global change. Here, we combined experimental evolution in Drosophila melanogaster with the genome-wide next-generation sequencing of DNA pools to identify alleles that are favorable in a different laboratory environment and traced their trajectories during the adaptive process. We applied logistic regression analysis that showed changes over time using the maximum likelihood method. After applying Bonferroni correction to adjust for multiple comparisons we found 12,166 significant genetic markers using a logistic regression approach whereas the commonly used Cochran-Mantel-Haenszel test identified 2254 significant genetic markers. Our results Provide a useful tool for testing the time-dependency of allele frequencies in genome-wide evolutionary experiment data.
목차
Abstract
1. Introduction
2. Materials and methods
3. Results
4. Discussion
5. Conclusion
References
참고문헌 (26)
참고문헌 신청
Agresti, A. / 2002 / Categorical data analysis / Wiley
Barrick, J. E. / 2009 / Genome evolution and adaptation in a long-term experiment with Escherichia coli / Nature 461:1243~1247
Burk, M. K. / 2010 / Genome-wide analysis of a long-term evolution experiment with Drosophila / Nature 467:587~590
Burk, M. K. / 2012 / What paths do advantageous allele take during short-term evolutionary change? / Molecular Ecology 21:4913~4916
Shiaoman Chao / 2010 / Population- and genome-specific patterns of linkage disequilibrium and SNP variation in spring and winter wheat (Triticum aestivum L.) / BMC Genomics 11(1)
Barrick, J. E. / 2009 / Genome evolution and adaptation in a long-term experiment with Escherichia coli / Nature 461:1243~1247
Burk, M. K. / 2010 / Genome-wide analysis of a long-term evolution experiment with Drosophila / Nature 467:587~590
Burk, M. K. / 2012 / What paths do advantageous allele take during short-term evolutionary change? / Molecular Ecology 21:4913~4916
Shiaoman Chao / 2010 / Population- and genome-specific patterns of linkage disequilibrium and SNP variation in spring and winter wheat (Triticum aestivum L.) / BMC Genomics 11(1)
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UCI(KEPA) : I410-ECN-0101-2019-041-000582569