지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 392 - 401 (10page)
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초록· 키워드
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We previously reported peritoneal innate-like integrin α4 (CD49d)<SUP>high</SUP>CD4+ T cells that provided help for B-1a cells. Here we analyzed the expression of various integrin chains on the peritoneal and pleural integrin α4highCD4<SUP>+</SUP> T cells and investigated the functional heterogeneity of the subpopulations based on the integrin expression. Pleural cavity contained a lower ratio of integrin α4<SUP>high</SUP>CD4<SUP>+</SUP> T cells to integrin α4<SUP>low</SUP>CD4<SUP>+</SUP> T cells than peritoneal cavity, but the pleural integrin α4<SUP>high</SUP>CD4<SUP>+</SUP> T cells have the same characteristics of the peritoneal integrin α4<SUP>high</SUP>CD4<SUP>+</SUP> T cells. Most of integrin α4highCD4+ T cells were integrin β1highβ7<SUP>−</SUP>, but a minor population of integrin α4<SUP>high</SUP>CD4<SUP>+</SUP> T cells was integrin β1+β7+. Interestingly, the integrin α4highβ1<SUP>high</SUP>β7<SUP>−</SUP> CD4<SUP>+</SUP> T cells expressed high levels of integrin α4β1 and α6β1, whereas integrin α4<SUP>high</SUP>β1<SUP>+</SUP>β7<SUP>+</SUP> CD4<SUP>+</SUP> T cells expressed high levels of integrin α4β1 and α4β7, suggesting an alternative expression of integrin α6β1 or α4β7 in combination with α4β1 in respective major and minor populations of integrin α4highCD4+ T cells. The minor population, integrin α4<SUP>high</SUP>β1<SUP>+</SUP>β7<SUP>+</SUP> CD4<SUP>+</SUP> T cells, were different from the integrin α4<SUP>high</SUP>β1<SUP>high</SUP>β7<SUP>−</SUP> CD4<SUP>+</SUP> T cells in that they secreted a smaller amount of Th1 cytokines upon stimulation and expressed lower levels of Th1-related chemokine receptors CCR5 and CXCR3 than the integrin α4<SUP>high</SUP>β1<SUP>high</SUP>β7<SUP>−</SUP> CD4<SUP>+</SUP> T cells. In summary, the innate-like integrin α4<SUP>high</SUP>CD4<SUP>+</SUP> T cells could be divided into 2 populations, integrin α4β1<SUP>+</SUP>α6β1<SUP>+</SUP>α4β7− and α4β1<SUP>+</SUP>α6β1<SUP>−</SUP>α4β7<SUP>+</SUP> cells. The functional significance of serosal integrin α4β7<SUP>+</SUP> CD4<SUP>+</SUP> T cells needed to be investigated especially in view of mucosal immunity.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (32)
참고문헌 신청
Haas KM. B-1 lymphocytes in mice and nonhuman primates. Ann N Y Acad Sci 2015;1362:98-109.
Ganshina IV. Serous cavities of coelomic origin as possible organs of the immune system. Part 1. Biol Bull Rev 2016;6:497-504.
Moon H, Park C, Lee JG, Shin SH, Lee JH, Kho I, Kang K, Cha HS, Kim TJ. Early development in the peritoneal cavity of CD49dhigh Th1 memory phenotype CD4+ T cells with enhanced B cell helper activity. J Immunol 2015;195:564-575.
Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, et al. Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis. J Exp Med 2014;211:1243-1256.
Rose DM, Han J, Ginsberg MH. Alpha4 integrins and the immune response. Immunol Rev 2002;186:118-124.
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UCI(KEPA) : I410-ECN-0101-2018-517-001663346