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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 87 - 92 (6page)
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초록· 키워드
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Objective Ubiquitin-specific peptidase 46 gene (USP46) polymorphisms is part of ubiquitin-proteasome system, which is responsible for dynamic cellular processes such as the regulation of cell cycle. USP46 has been reported to be associated with major depressive disorder. The objective of the present study was to investigate the association of USP46 polymorphisms with affective temperamental traits in healthy subjects. Methods A total of 557 Korean healthy volunteers were recruited, and 545 subjects (328 male, 217 female) were included in the final analysis. The DNA of the subjects was isolated from saliva samples. Two single-nucleotide polymorphisms (SNPs) rs346005, rs2244291 in USP46 were genotyped. Affective temperaments were assessed using the Korean version of Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A). Results A significant association was found between rs346005 genotypes and TEMPS-A only in male subjects. In particular, subjects with the CC genotype of rs346005 showed a more depressive temperament than subjects with AA or CA genotypes in males. For rs2244291, there were no associations between the rs2244291 genotypes and TEMPS-A scores. Conclusion Some affective temperaments may serve as a genetic predisposing factors for affective disorders, such as depressive disorder, via vulnerability genes related to the ubiquitin-proteasome system.
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등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Akiskal HS / 2005 / TEMPSA : progress towards validation of a self-rated clinical version of the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire / J Affect Disord 85:3~16
Kawamura Y / 2010 / Six-year stability of affective temperaments as measured by TEMPSA / Psychopathology 43:240~247
Nigg JT / 2006 / Temperament and developmental psychopathology / J Child Psychol Psychiatry 47:395~422
Kraepelin E / 1921 / Manic-Depressive Insanity and Paranoia / E. & S. Livingstone
Toda H / 2016 / Affective temperaments play an important role in the relationship between childhood abuse and depressive symptoms in major depressive disorder / Psychiatry Res 236:142~147
Kawamura Y / 2010 / Six-year stability of affective temperaments as measured by TEMPSA / Psychopathology 43:240~247
Nigg JT / 2006 / Temperament and developmental psychopathology / J Child Psychol Psychiatry 47:395~422
Kraepelin E / 1921 / Manic-Depressive Insanity and Paranoia / E. & S. Livingstone
Toda H / 2016 / Affective temperaments play an important role in the relationship between childhood abuse and depressive symptoms in major depressive disorder / Psychiatry Res 236:142~147
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