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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 264 - 271 (8page)
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Here, we aimed to study the effect of the forkhead box O1-insulin receptor substrate 2 (FOXO1-IRS2) gene interaction and the FOXO1 and IRS2 genes-environment interaction for the risk of type 2 diabetes mellitus (T2DM) in a Chinese Han population. We genotyped 7 polymorphism sites of FOXO1 gene and IRS2 gene in 780 unrelated Chinese Han people (474 cases of T2DM, 306 cases of healthy control). The risk of T2DM in individuals with AA genotype for rs7986407 and CC genotype for rs4581585 in FOXO1 gene was 2.092 and 2.57 times higher than that with GG genotype (odds ratio [OR] = 2.092; 95% confidence interval [CI] = 1.178–3.731; P = 0.011) and TT genotype (OR = 2.571; 95% CI = 1.404–4.695; P = 0.002), respectively. The risk of T2DM in individuals with GG genotype for Gly1057Asp in IRS2 gene was 1.42 times higher than that with AA genotype (OR = 1.422; 95% CI = 1.037–1.949; P = 0.029). The other 4 single nucleotide polymorphisms (SNPs) had no significant association with T2DM (P > 0.05). Multifactor dimensionality reduction (MDR) analysis showed that the interaction between SNPs rs7986407 and rs4325426 in FOXO1 gene and waist was the best model confirmed by interaction analysis, closely associating with T2DM. There was an increased risk for T2DM in the case of non-obesity with genotype combined AA/CC, AA/AC or AG/AA for rs7986407 and rs4325426, and obesity with genotype AA for rs7986407 or AA for rs4325426 (OR = 3.976; 95% CI = 1.156–13.675; P value from sign test [Psign] = 0.025; P value from permutation test [Pperm] = 0.000–0.001). Together, this study indicates an association of FOXO1 and IRS2 gene polymorphisms with T2DM in Chinese Han population, supporting FOXO1-obesity interaction as a key factor for the risk of T2DM.
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참고문헌 (27)
참고문헌 신청
Edelman SV / 1998 / Type II diabetes mellitus / Adv Intern Med 43:449~500
Voight BF / 2010 / Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis / Nat Genet 42:579~589
O’Rahilly S / 2005 / Genetic factors in type 2 diabetes: the end of the beginning? / Science 307:370~373
Wild S / 2004 / Global prevalence of diabetes : estimates for the year 2000 and projections for 2030 / Diabetes Care 27:1047~1053
Chan JC / 2009 / Diabetes in Asia: epidemiology, risk factors, and pathophysiology / JAMA 301:2129~2140
Voight BF / 2010 / Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis / Nat Genet 42:579~589
O’Rahilly S / 2005 / Genetic factors in type 2 diabetes: the end of the beginning? / Science 307:370~373
Wild S / 2004 / Global prevalence of diabetes : estimates for the year 2000 and projections for 2030 / Diabetes Care 27:1047~1053
Chan JC / 2009 / Diabetes in Asia: epidemiology, risk factors, and pathophysiology / JAMA 301:2129~2140
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