Interferon-γ and Interleukin-10 Gene Polymorphisms are not Predictors of Chronic Hepatitis C (Genotype-4) Disease Progression

Bahgat, Nermine Ahmed; Kamal, Manal Mohamed; Abdelaziz, Ashraf Omar; Mohye, Mohamed Ahmed; Shousha, Hend Ibrahim; ahmed, Mae Mohamed; Elbaz, Tamer Mahmoud; Nabil, Mohamed Mahmoud

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자료유형: 학술저널

저자정보: Bahgat, Nermine Ahmed (Clinical and Chemical Pathology Department, Faculty of medicine, Cairo University) Kamal, Manal Mohamed (Clinical and Chemical Pathology Department, Faculty of medicine, Cairo University) Abdelaziz, Ashraf Omar (Endemic medicine and Hepatogastroenterology Department, Faculty of Medicine, Cairo University) Mohye, Mohamed Ahmed (Endemic medicine and Hepatogastroenterology Department, Faculty of Medicine, Cairo University) Shousha, Hend Ibrahim (Endemic medicine and Hepatogastroenterology Department, Faculty of Medicine, Cairo University) ahmed, Mae Mohamed (Clinical and Chemical Pathology Department, Faculty of medicine, Cairo University) Elbaz, Tamer Mahmoud (Endemic medicine and Hepatogastroenterology Department, Faculty of Medicine, Cairo University) Nabil, Mohamed Mahmoud (Endemic medicine and Hepatogastroenterology Department, Faculty of Medicine, Cairo University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제12호

발행연도: 2015.1

수록면: 5,025 - 5,030 (6page)

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Immunoregulatory cytokines have an influence on hepatitis C virus (HCV) infection outcome. This study aimed to determine whether single nucleotide polymorphisms (SNP) in IFN- ${\gamma}$ and IL-10 genes are associated with susceptibility and/or are markers of prognosis regarding chronic hepatitis C outcomes. IFN ${\gamma}$ (+874T/A) and IL-10 (-1082G/A) genotypes were determined in 75 HCV genotype 4 patients with different disease severities (chronic hepatitis, n=25, liver cirrhosis and hepatocellular carcinoma (HCC) on top of liver cirrhosis, n=50) and 25 healthy participants using allele-specific polymerase chain reaction. No statistical differences in allele or genotype distributions of IFN ${\gamma}$ and IL-10 genes were detected between patients and controls or between patientgroups. No significant difference in the frequency of IL-10 SNP at position -1082 or IFN-${\gamma}$ at position +874T/A was found between chronic HCV genotype 4 and with progression of disease severity in liver cirrhosis or HCC. In conclusion; interferon-${\gamma}$ and interleukin-10 gene polymorphisms are not predictors of disease progression in patients with chronic hepatitis C (Genotype-4).

#Chronic hepatitis C #single nucleotide polymorphism #IFN- ${gamma}$ #IL-10 #HCV genotype 4

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