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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective : Dynamic proteolysis, through the ubiquitin-proteasome system, is an important molecular mechanism for the constant regulation of synaptic plasticity and stress responses in humans. In this study, we examined whether genetic variants in the ubiquitin-specific peptidase (USP) genes were associated with psychological traits of resilience and susceptibility to neuropsychiatric disorders for each gender. Methods : A total of 344 Korean healthy youths (190 males, 154 females) were included in the study. A genotyping of rs2241646 of USP2 and rs346006 of USP46 was performed. The Connor–Davidson Resilience Scale and Brief Fear of Negative Evaluation Scale were administered for measuring trait resilience and social anxiety, respectively. The genetic associations of the USP variants were tested using multiple analyses of covariance with psychological traits as dependent variables after controlling for age in each gender. Results : For USP2 rs2241646, women with the TT genotype showed significantly higher resilience and lower social anxiety, as compared to those carrying the C allele. There were no associations between USP46 rs346005 and the psychological traits in both genders. Conclusions : The present study showed a possible genetic association between the USP2 rs2241646 and stress resilience and trait anxiety in women. The findings suggest that ubiquitin-proteasome system may be related to the resilience and susceptibility to stress-related neuropsychiatric disorders such as anxiety disorders, possibly through the regulation of dynamic proteolysis responses to stress. (Anxiety and Mood 2019;15(2):122-126)
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참고문헌 (39)
참고문헌 신청
Cheon S, Dean M, Chahrour M / 2018 / The ubiquitin proteasome pathway in neuropsychiatric disorders / Neurobiol Learn Mem
Nalepa G / 2006 / Drug discovery in the ubiquitinproteasome system / Nat Rev Drug Discov 5:596~613
Dong C / 2014 / Proteasome modulates positive and negative translational regulators in long-term synaptic plasticity / J Neurosci 34:3171~3182
Li Q / 2016 / Ubiquitin-Proteasome System Inhibition Promotes Long-Term Depression and Synaptic Tagging/Capture / Cereb Cortex 26:2541~2548
Cai F / 2010 / Protein degradation by the proteasome is required for synaptic tagging and the heterosynaptic stabilization of hippocampal late-phase long-term potentiation / Neuroscience 169:1520~1526
Nalepa G / 2006 / Drug discovery in the ubiquitinproteasome system / Nat Rev Drug Discov 5:596~613
Dong C / 2014 / Proteasome modulates positive and negative translational regulators in long-term synaptic plasticity / J Neurosci 34:3171~3182
Li Q / 2016 / Ubiquitin-Proteasome System Inhibition Promotes Long-Term Depression and Synaptic Tagging/Capture / Cereb Cortex 26:2541~2548
Cai F / 2010 / Protein degradation by the proteasome is required for synaptic tagging and the heterosynaptic stabilization of hippocampal late-phase long-term potentiation / Neuroscience 169:1520~1526
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