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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제2호
- 발행연도
- 2019.1
- 수록면
- 268 - 273 (6page)
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The specificity of a Bacillus licheniformis uridine diphosphate (UDP) glycosyltransferase, YjiC, was increased towards thymidine diphosphate (TDP)-sugar by site-directed mutagenesis. The Arg-282 of YjiC was identified and investigated by substituting with Trp. Conversion rate and kinetic parameters were compared between YjiC and its variants with several acceptor substrates such as 7-hydroxyflavone (7-HF), 4’,7-dihydroxyisoflavone, 7,8-dihydroxyflavone and curcumin. Molecular docking of TDP-glucose and 7-HF with YjiC model showed pi-alkyl interaction with Arg-282 and His-14, and pi-pi interaction with His14 and thymine ring. YjiC (H14A) variant lost its glucosylation activity with TDP-glucose validating significance of His- 14 in binding of TDP-sugars.
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참고문헌 (24)
참고문헌 신청
Salas JA / 2007 / Engineering the glycosylation of natural products in actinomycetes / Trends Microbiol 15:219~232
Thibodeaux CJ / 2008 / Naturalproduct sugar biosynthesis and enzymatic glycodiversification / Angew. Chem. Int. Ed. Engl 47:9814~9859
Pandey RP / 2013 / Enzymatic synthesis of novel phloretin glucosides / Appl. Environ. Microbiol 79:3516~3521
Pandey RP / 2013 / Probing 3-hydroxyflavone for in vitro glycorandomization of flavonols by YjiC / Appl. Environ. Microbiol 79:6833~6838
Pandey RP / 2014 / Assessing acceptor substrate promiscuity of YjiC-mediated glycosylation toward flavonoids / Carbohydr. Res 393:26~31
Thibodeaux CJ / 2008 / Naturalproduct sugar biosynthesis and enzymatic glycodiversification / Angew. Chem. Int. Ed. Engl 47:9814~9859
Pandey RP / 2013 / Enzymatic synthesis of novel phloretin glucosides / Appl. Environ. Microbiol 79:3516~3521
Pandey RP / 2013 / Probing 3-hydroxyflavone for in vitro glycorandomization of flavonols by YjiC / Appl. Environ. Microbiol 79:6833~6838
Pandey RP / 2014 / Assessing acceptor substrate promiscuity of YjiC-mediated glycosylation toward flavonoids / Carbohydr. Res 393:26~31
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