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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 317 - 324 (8page)
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Background Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) was induced in hypoxia and participated in cancer development. However, the role of PLOD2 in endometrial carcinoma remains unclear. Objective To explore the influences and regulation mechanism of PLOD2 in endometrial carcinoma under hypoxic condition. Methods The small interfering RNA (siRNA) targeting to PLOD2 and pcDNA3.1-PLPD2 were transfected to endometrial carcinoma cells to alter PLOD2 expression. Cell proliferation ability was determined by colony formation assay. Wound healing assay used to detect cell migration ability. Transwell invasion assay was used to detect cell invasion ability. Results PLOD2 and Hypoxia-inducible factor-1α (HIF-1α) were induced by hypoxia. Down-regulation of PLOD2 did not affect endometrial carcinoma cell proliferation ability, while inhibited cell migration, invasion under hypoxic condition. Besides, down-regulation of PLOD2 increased the levels of γ-catenin and E-cadherin and decreased levels of Fibronectin and Snail under hypoxic condition. Down-regulation of PLOD2 also inactivated Src and phosphoinositide 3-kinase (PI3K)/ protein kinase B (Akt) signaling under hypoxic condition. The promoting effects of PLOD2 overexpression on migration, invasion and epithelial-mesenchymal transition (EMT) of endometrial carcinoma cells were reversed by Akt inhibitor (MK2206) under hypoxic condition. Conclusion PLOD2 expression was increased in endometrial carcinoma cells under hypoxic condition. PLOD2 modulated migration, invasion, and EMT of endometrial carcinoma cells via PI3K/Akt signaling. PLOD2 may be a potential therapeutic target for endometrial carcinoma.
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참고문헌 (25)
참고문헌 신청
Birchmeier C / 1996 / Epithelial-mesenchymal transitions in cancer progression / Acta Anat 156:217~226
Chen S / 2018 / LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein / Biochim Biophys Acta Mol Basis Dis 1864:3013~3021
Digiacomo G / 2018 / Overcoming palbociclib resistance by combined treatment with PI3K/AKT/mTOR inhibitors in mesothelioma cells / J Mol Clin Med 1:151~156
Du H / 2017 / PLOD2 regulated by transcription factor FOXA1 promotes metastasis in NSCLC / Cell Death Dis 8:e3143
Fischer KR / 2015 / Epithelial-tomesenchymal transition is not required for lung metastasis but contributes to chemoresistance / Nature 527:472
Chen S / 2018 / LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein / Biochim Biophys Acta Mol Basis Dis 1864:3013~3021
Digiacomo G / 2018 / Overcoming palbociclib resistance by combined treatment with PI3K/AKT/mTOR inhibitors in mesothelioma cells / J Mol Clin Med 1:151~156
Du H / 2017 / PLOD2 regulated by transcription factor FOXA1 promotes metastasis in NSCLC / Cell Death Dis 8:e3143
Fischer KR / 2015 / Epithelial-tomesenchymal transition is not required for lung metastasis but contributes to chemoresistance / Nature 527:472
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