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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제7호
- 발행연도
- 2020.1
- 수록면
- 1,092 - 1,096 (5page)
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초록· 키워드
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YjiC, a glycosyltransferase from Bacillus licheniformis, is a well-known versatile enzyme for glycosylation of diverse substrates. Although a number of O-glycosylated products have been produced using YjiC, no report has been updated for nucleophilic N-, S-, and C- glycosylation. Here, we report the additional functional capacity of YjiC for nucleophilic N- and S- glycosylation using a broad substrate spectrum including UDP-α-D-glucose, UDP-N-acetyl glucosamine, UDP-N-acetylgalactosamine, UDP-α-D-glucuronic acid, TDP-α-L-rhamnose, TDP-α-D-viosamine, and GDP-α-Lfucose as donor and various amine and thiol groups containing natural products as acceptor substrates. The results revealed YjiC as a promiscuous enzyme for conjugating diverse sugars at amine and thiol functional groups of small molecules applicable for generating glycofunctionalized chemical diversity libraries. The glycosylated products were analyzed using HPLC and LC/MS and compared with previous reports.
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참고문헌 (21)
참고문헌 신청
Kilcoyne M / 2007 / Carbohydrates in therapeutics / Cardiovasc. Hematol. Agents Med. Chem 5:1876~1897
Kren V / 2001 / Glycosides in medicine : "The role of glycosidic residue in biological activity" / Curr. Med. Chem 8:1303~1328
Křen V / 2008 / Sweet antibiotics-The role of glycosidic residues in antibiotic and antitumor activity and their randomization / FEMS Microbiol. Rev 32:858~889
Wrodnigg TM / 2004 / Bioactive carbohydrates and recently discovered analogues as chemotherapeutics / Mini Rev. Med. Chem 4:437~459
Campbell JA / 1997 / A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities / Biochem. J 326:929~939
Kren V / 2001 / Glycosides in medicine : "The role of glycosidic residue in biological activity" / Curr. Med. Chem 8:1303~1328
Křen V / 2008 / Sweet antibiotics-The role of glycosidic residues in antibiotic and antitumor activity and their randomization / FEMS Microbiol. Rev 32:858~889
Wrodnigg TM / 2004 / Bioactive carbohydrates and recently discovered analogues as chemotherapeutics / Mini Rev. Med. Chem 4:437~459
Campbell JA / 1997 / A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities / Biochem. J 326:929~939
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