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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제1호
- 발행연도
- 2016.1
- 수록면
- 56 - 60 (5page)
이용수
초록· 키워드
오류제보하기
Two new glucosides (1 and 2) of geldanamycin (GA) analogs were obtained from in vitro glycosylation by UDP-glycosyltransferase (YjiC). Based on spectroscopic (HR-ESI-MS, 1D, and 2D-NMR) analyses, the glucosides were elucidated as 4,5-dihydro-7-O-descarbamoyl-7- hydroxyl GA-7-O-β-D-glucoside (1) and ACDL3172-18-O-β-D-glucoside (2). Furthermore, the water solubility of compounds 1 and 2 was about 215.2 and 90.7 times higher respectively, than that of the substrates. Among compounds 1-4, only 3 showed weak antiproliferative activity against four human tumor cell lines: MDA-MB-231, SMMC7721, HepG2, and SW480 (IC50: 13.6, 15.1, 31.8, and 22.7 μM, respectively).
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Cheng H / 2005 / Synthesis and enzyme-specific activation of carbohydrategeldanamycin conjugates with potent anticancer activity / J. Med. Chem 48:645~652
DeBoer C / 1970 / Geldanamycin, a new antibiotic / J. Antibiot. (Tokyo) 23:442~447
Dhakal D / 2015 / Enhanced production of nargenicin A1 and generation of novel glycoslated derivatives / Appl. Biochem. Biotechnol 175:2934~2949
Elshahawi SI / 2015 / A comprehensive review of glycosylated bacterial natural products / Chem. Soc. Rev
Fukuyo Y / 2009 / Geldanamycin and its anti-cancer activities / Cancer Lett 290:24~35
DeBoer C / 1970 / Geldanamycin, a new antibiotic / J. Antibiot. (Tokyo) 23:442~447
Dhakal D / 2015 / Enhanced production of nargenicin A1 and generation of novel glycoslated derivatives / Appl. Biochem. Biotechnol 175:2934~2949
Elshahawi SI / 2015 / A comprehensive review of glycosylated bacterial natural products / Chem. Soc. Rev
Fukuyo Y / 2009 / Geldanamycin and its anti-cancer activities / Cancer Lett 290:24~35
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