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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제6호
- 발행연도
- 2019.1
- 수록면
- 856 - 862 (7page)
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초록· 키워드
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A series of thienopyrimidine compounds (6Aa–g and 6Ba–d) were synthesized and characterized by NMR spectroscopy and mass spectrometry. These compounds (6Aa–g and 6Ba–d) potently inhibited STAT3 expression induced by IL-6 in a dose-dependent manner with IC50 values of 5.73–0.32 μM. Among the prepared thienopyrimidine derivatives, 6Aa, 6Ab, 6Ba and 6Bc significantly suppressed the phosphorylation of STAT3 and ERK1/2 stimulated by IL-6 in Hep3B cells. Furthermore, the synthesized compounds might be useful remedies for the treatment of inflammatory diseases by inhibiting the action of IL-6.
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참고문헌 (32)
참고문헌 신청
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Feldmann M / 1996 / Rheumatoid arthritis / Cell 85:307~310
Carson DA / 1991 / New roles for rheumatoid factor / J, Clin. Invest 87:379~383
Hogg N / 2002 / Mechanisms contributing to the activity of integrins on leukocytes / Immunol. Rev 186:164~171
Shimaoka M / 2003 / Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation / Cell 112:99~111
Feldmann M / 1996 / Rheumatoid arthritis / Cell 85:307~310
Carson DA / 1991 / New roles for rheumatoid factor / J, Clin. Invest 87:379~383
Hogg N / 2002 / Mechanisms contributing to the activity of integrins on leukocytes / Immunol. Rev 186:164~171
Shimaoka M / 2003 / Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation / Cell 112:99~111
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