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논문 기본 정보

자료유형
학술저널
저자정보
Choe, Ji-Hyun (Division of Biotechnology, Advanced Institute of Environment and Bioscience, College of Environmental & Bioresources, Chonbuk National University) Yi, Young-Joo (Division of Biotechnology, Advanced Institute of Environment and Bioscience, College of Environmental & Bioresources, Chonbuk National University) Lee, Myeong-Seok (Division of Biotechnology, Advanced Institute of Environment and Bioscience, College of Environmental & Bioresources, Chonbuk National University) Seo, Dong-Won (Division of Biotechnology, Advanced Institute of Environment and Bioscience, College of Environmental & Bioresources, Chonbuk National University) Yun, Bong-Sik (Division of Biotechnology, Advanced Institute of Environment and Bioscience, College of Environmental & Bioresources, Chonbuk National University) Lee, Sang-Myeong (Division of Biotechnology, Advanced Institute of Environment and Bioscience, College of Environmental & Bioresources, Chonbuk National University)
저널정보
한국균학회 Mycobiology Mycobiology 제43권 제3호
발행연도
2015.1
수록면
319 - 326 (8page)

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Fomes fomentarius is a fungus of the Polyporaceae family and is used in traditional oriental therapies. Although the anti-inflammatory activities of this species have been previously reported, the identity of the bioactive compounds responsible for this activity remains unknown. Here, we investigated whether methyl 9-oxo-(10E,12E)-octadecadienoate (FF-8) purified from F. fomentarius exerts anti-inflammatory activity in murine macrophages stimulated with lipopolysaccharide (LPS). FF-8 suppressed secretion of nitric oxide (NO) and prostaglandin $E_2$ through downregulation of inducible NO synthase and cyclooxygenase-2 expression induced by LPS. In addition, pretreatment of cells with FF-8 led to a reduction in levels of secreted inflammatory cytokines such as tumor necrosis factor-${\alpha}$ and interleukin-6 in macrophages stimulated with LPS. Conversely, FF-8 did not affect nuclear factor ${\kappa}B$, p38, c-Jun NH2-terminal kinase, and extracellular signal-regulated kinase pathways. Instead, FF-8 specifically interfered with signal transducer and activator of transcription 3 (STAT3) phosphorylation induced by LPS. Collectively, this study demonstrated that FF-8 purified from F. fomentarius suppresses inflammatory responses in macrophages stimulated with LPS by inhibiting STAT3 activation. Further studies will be required to elucidate the anti-inflammatory effect of FF-8 in vivo.
#Anti-inflammatory effect #Fomes fomentarius #Macrophages #STAT3

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참고문헌 (29)

참고문헌 신청
Liaunardy-Jopeace A / 2014 / Molecular and cellular regulation of Toll-like receptor-4 activity induced by lipopolysaccharide ligands / Front Immunol 5:473 google schola Fresno M / 2011 / Toll-like receptors, inflammation, metabolism and obesity / Arch Physiol Biochem 117:151~164 google schola Monaco C / 2011 / Toll-like receptor signaling: common pathways that drive cardiovascular disease and rheumatoid arthritis / Arthritis Care Res 63:500~511 google schola Fujihara M / 2003 / Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex / Pharmacol Ther 100:171~194 google schola Kaminska B / 2005 / MAPK signalling pathways as molecular targets for anti-inflammatory therapy: from molecular mechanisms to therapeutic benefits / Biochim Biophys Acta 1754:253~262 google schola

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