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Cancer is a leading cause of death worldwide. The roles and significance of Signal Transducer and Activator ofTranscription 3 (STAT3) in human cancers have been extensively studied. STAT3 is a promising therapeutic target for cancerdrug discovery. Herbal medicine-derived secondary metabolites efficiently impact all cancer hallmarks; therefore, naturalproducts are a major source of new cancer drug development. Many natural products can inhibit STAT signaling pathwaysin cancer cells by targeting different pathways. In this review, we describe the structures of STAT3 inhibitors isolated fromherbal medicines and discuss their targeting molecules and modes of action.
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참고문헌 (82)
참고문헌 신청
Akaberi, M. / 2015 / Multiple pro-apoptotic targets of abietane diterpenoids from Salvia species / Fitoterapia 100:118~132
Ahn, K. S. / 2008 / Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a proteintyrosine phosphatase SHP-1 / Cancer Res 68:4406~4415
Almazari, J. / 2013 / Cancer chemopreventive and therapeutic potential of guggulsterone / Top Curr Chem 329:35~60
Amni, B. / 2016 / Black Cumin (Nigella sativa) and its active constituent, thymoquinone: An overview on the analgesic and anti-inflammatory effects / Planta Med 82:8~16
Arumuggam, N. / 2015 / Phytochemicals targeting JAK/STAT signaling and IDO expression in cancer / Phytother Res 29:805~817
Ahn, K. S. / 2008 / Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a proteintyrosine phosphatase SHP-1 / Cancer Res 68:4406~4415
Almazari, J. / 2013 / Cancer chemopreventive and therapeutic potential of guggulsterone / Top Curr Chem 329:35~60
Amni, B. / 2016 / Black Cumin (Nigella sativa) and its active constituent, thymoquinone: An overview on the analgesic and anti-inflammatory effects / Planta Med 82:8~16
Arumuggam, N. / 2015 / Phytochemicals targeting JAK/STAT signaling and IDO expression in cancer / Phytother Res 29:805~817
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