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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제3호
- 발행연도
- 2020.1
- 수록면
- 325 - 332 (8page)
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Methyl linderone (ML), a cyclo-pentenedione, was isolated from the fruit of Lindera erythrocarpa Makino (family Lauraceae). This plant has well-known anti-inflammatory effects; however, the anti-cancer effects of ML have not yet been reported. Thus, in the present study we investigated the effects of ML on the metastasis of human breast cancer cells. We used 12- O-tetradecanoyl phorbol-13-acetate (TPA)-stimulated MCF-7 cells as the cell model to study the effects of ML on invasion and migration. ML was found to reduce the invasion and migration rate of TPA-stimulated MCF-7 cells. Moreover, it inhibited two metastasis-related factors, matrix metalloproteinase-9 (MMP-9) and interleukin-8 (IL-8), at the mRNA and protein expression levels, in TPA-treated MCF-7 cells. The mechanism by which ML exerted these effects was through the inhibition of translocation of activator protein-1 (AP-1) and signal transducer and activator of transcription-3 (STAT3), mediated via phosphorylation of extracellular signal-regulated kinase (ERK). Taken together, our findings indicated that ML attenuated the TPA-stimulated invasion and migration of MCF-7 cells by suppressing the phosphorylation of ERK and its downstream factors, AP-1 and STAT3. Therefore, ML is a potential agent for the treatment of breast cancer metastasis.
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참고문헌 (26)
참고문헌 신청
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J. Clin 65:87~108
이진탁 / 2020 / Kanakugiol, a Compound Isolated from Lindera erythrocarpa, Promotes Cell Death by Inducing Mitotic Catastrophe after Cell Cycle Arrest / Journal of Microbiology and Biotechnology 30(2):279~286
Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36cancers in 185 countries / CA Cancer J. Clin 68:394~424
Ferlay J / 2013 / Cancer incidence and mortality patterns in Europe : estimates for 40 countries in 2012 / Eur. J. Cancer 49:1374~1403
Chambers AF / 1997 / Changing views of the role of matrix metalloproteinases in metastasis / J. Natl. Cancer Inst 89:1260~1270
이진탁 / 2020 / Kanakugiol, a Compound Isolated from Lindera erythrocarpa, Promotes Cell Death by Inducing Mitotic Catastrophe after Cell Cycle Arrest / Journal of Microbiology and Biotechnology 30(2):279~286
Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36cancers in 185 countries / CA Cancer J. Clin 68:394~424
Ferlay J / 2013 / Cancer incidence and mortality patterns in Europe : estimates for 40 countries in 2012 / Eur. J. Cancer 49:1374~1403
Chambers AF / 1997 / Changing views of the role of matrix metalloproteinases in metastasis / J. Natl. Cancer Inst 89:1260~1270
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