지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 133 - 138 (6page)
이용수
초록· 키워드
오류제보하기
Upon viral infection, the 2’, 5’-oligoadenylate synthetase (OAS)-ribonuclease L (RNaseL) system works to cleave viral RNA, thereby blocking viral replication. However, it is unclear whether OAS proteins have a role in regulating gene expression. Here, we show that OAS1 and OAS3 act as negative regulators of the expression of chemokines and interferonresponsive genes in human macrophages. Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein-9 nuclease (Cas9) technology was used to engineer human myeloid cell lines in which the OAS1 or OAS3 gene was deleted. Neither OAS1 nor OAS3 was exclusively responsible for the degradation of rRNA in macrophages stimulated with poly(I:C), a synthetic surrogate for viral double-stranded (ds)RNA. An mRNA sequencing analysis revealed that genes related to type I interferon signaling and chemokine activity were increased in OAS1−/− and OAS3−/− macrophages treated with intracellular poly(I:C). Indeed, retinoic-acid-inducible gene (RIG)-I- and interferon-induced helicase C domain-containing protein (IFIH1 or MDA5)-mediated induction of chemokines and interferon-stimulated genes was regulated by OAS3, but Toll-like receptor 3 (TLR3)- and TLR4-mediated induction of those genes was modulated by OAS1 in macrophages. However, stimulation of these cells with type I interferons had no effect on OAS1- or OAS3- mediated chemokine secretion. These data suggest that OAS1 and OAS3 negatively regulate the expression of chemokines and interferon-responsive genes in human macrophages.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases
Experimental and Molecular Medicine
2015 .01
-
OAS(OpenAPI Specification)을 활용한 주행 데이터 분석 OpenAPI 서비스 구조
한국통신학회 학술대회논문집
2021 .06
-
분산 디바이스 기반 비정형 데이터 수집 시스템
한국통신학회 학술대회논문집
2022 .06
-
Increased Gene Cloning and Protein Expression of Interferon
한국생물공학회 학술대회
2023 .04
-
An inhibitory alternative splice isoform of Toll-like receptor 3 is induced by type I interferons in human astrocyte cell lines
BMB Reports
2015 .01
-
코돈 최적화된 유전자를 이용한 재조합 대장균으로부터 인간 인터페론 베타 발현
KSBB Journal
2017 .03
-
Development of High Efficiency Non-Viral Gene Delivery System
한국생물공학회 학술대회
2020 .06
-
센서네트워크 기반의 수중, 수상 및 공중 로봇의 협력제어 기법
전기학회논문지
2016 .01
-
Current Trends in Viral Gene Therapy for Human Orthopaedic Regenerative Medicine
조직공학과 재생의학
2019 .01
-
Regulation of cellular gene expression by nanomaterials
Nano Convergence
2018 .11
-
Development of cell culture process for the production of recombinant human interferon-beta
한국생물공학회 학술대회
2019 .10
-
Predicting Gene Expressions from Gene Expressions : Comparison between Lasso and Random Forest
한국정보과학회 학술발표논문집
2018 .06
-
Metabolic influence on macrophage polarization and pathogenesis
BMB Reports
2019 .01
-
Gene Expression Mediating Messenger RNA Nanoparticles
한국고분자학회 학술대회 연구논문 초록집
2015 .10
-
다발성경화증 치료를 위한 인터페론 베타의 산업적 생산
KSBB Journal
2018 .06
-
Modulation of Gene Expression using Synthetic Regulatory Small RNas in Escherichia coli
한국생물공학회 학술대회
2017 .04
-
Myeloid cell-specific sirtuin 6 deficiency delays wound healing in mice by modulating inflammation and macrophage phenotypes
Experimental and Molecular Medicine
2019 .01
-
Modification of Signal Peptide for Enhanced Production of Recombinant Human Interferon-beta from Mammalian Cells
한국생물공학회 학술대회
2018 .04
-
Label-Free and Real-Time Electrical Impedance Monitoring of Macrophage Polarization of THP-1 Monocytes on Indium Tin Oxide Electrode
BioChip Journal
2024 .03
-
Development of a Non-viral Oral Gene Delivery System for the Treatment of Type 2 Diabetes Mellitus
한국생물공학회 학술대회
2023 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0