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The study of antiviral pathways to reveal methods for the effective response and clearance of virus is closely related to understanding interferon (IFN) signaling and its downstream target genes, IFN-stimulated genes. One of the key antiviral factorsinduced by IFNs, 2′-5′ oligoadenylate synthase (OAS), is a well-known molecule that regulates the early phase of viral infection by degrading viral RNA in combination with RNase L, resulting in the inhibition of viral replication. In this review, we describe OAS family proteins from a different point of view from that of previous reviews. We discuss not only RNase L-dependent (canonical) and -independent (noncanonical) pathways but also the possibility of the OAS family members as biomarkers for various diseases and clues to non-immunological functions based on recent studies. In particular, we focus on OASL, a member of the OAS family that is relatively less well understood than the other members. We will explain its anti- and pro-viral dual roles as well as the diseases related to single-nucleotide polymorphisms in the corresponding gene.
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참고문헌 (23)
참고문헌 신청
Alagarasu K / 2013 / Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection / Infect Genet Evol 14
Bonnevie-Nielsen V / 2005 / Variation in antiviral 2',5'-oligoadenylate synthetase (2' 5' AS) enzyme activity is controlled by a single-nucleotide polymorphism at a spliceacc
Bordignon J / 2008 / Expression profile of interferon stimulated genes in central nervous system of mice infected with dengue virus Type-1 / Virology 377 : 319 ~ 329
Brehin AC / 2009 / The large form of human 2',5'-oligoadenyl
Chakrabarti A / 2011 / New insights into the role of RNase L in innate immunity / J Interferon Cytokine Res 31 : 49 ~ 57
Bonnevie-Nielsen V / 2005 / Variation in antiviral 2',5'-oligoadenylate synthetase (2' 5' AS) enzyme activity is controlled by a single-nucleotide polymorphism at a spliceacc
Bordignon J / 2008 / Expression profile of interferon stimulated genes in central nervous system of mice infected with dengue virus Type-1 / Virology 377 : 319 ~ 329
Brehin AC / 2009 / The large form of human 2',5'-oligoadenyl
Chakrabarti A / 2011 / New insights into the role of RNase L in innate immunity / J Interferon Cytokine Res 31 : 49 ~ 57
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