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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 696 - 701 (6page)
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Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA. It stimulates pro-inflammatory cytokine and interferon production. Here we reported the expression of a novel isoform of TLR3 in human astrocyte cell lines whose message is generated by alternative splicing. The isoform represents the N-terminus of the protein. It lacks many of the leucine-rich repeat domains, the transmembrane domain, and the intracellular Toll/interleukin-1 receptor domain of TLR3. Type I interferons (interferon- and interferon-) induced the expression of this isoform. Exogenous overexpression of this isoform inhibited interferon regulatory factor 3, signal transducers and activators of transcription 1, and Inhibitor of kappa B signaling following stimulation. This isoform of TLR3 also inhibited the production of chemokine interferon--inducible protein 10.
Our study clearly demonstrated that the expression of this isoform of TLR3 was a negative regulator of signaling pathways and that it was inducible by type I interferons. We also found that this isoform could modulate inflammation in the brain.
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참고문헌 (26)
참고문헌 신청
Chockalingam A / 2011 / Negative regulation of signaling by a soluble form of toll-like receptor 9 / Eur J Immunol 41 : 2176 ~ 2184
Costello DA / 2013 / Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-beta / Hippocampus 23 : 696 ~ 707
Dakovic I / 2014 / Clinical features of cerebral palsy in children with symptomatic congenital cytomegalovirus infection / Eur J Paediatr Neurol 18 : 618 ~ 623
Ewald SE / 2011 / Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase / J Exp Med 208 : 643 ~ 651
Farina C / 2005 / Preferential expression and function of Toll-like receptor 3 in human astrocytes / J Neuroimmunol 159 : 12 ~ 19
Costello DA / 2013 / Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-beta / Hippocampus 23 : 696 ~ 707
Dakovic I / 2014 / Clinical features of cerebral palsy in children with symptomatic congenital cytomegalovirus infection / Eur J Paediatr Neurol 18 : 618 ~ 623
Ewald SE / 2011 / Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase / J Exp Med 208 : 643 ~ 651
Farina C / 2005 / Preferential expression and function of Toll-like receptor 3 in human astrocytes / J Neuroimmunol 159 : 12 ~ 19
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