지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background: Bisphosphonate (BP) is an effective drug for the prevention and treatment of osteoporosis. However, gastrointestinal distress caused by BP is a well-known side effect for low compliance. The aim of our study was to compare the 1-year persistence, compliance and T-scores between the aperitif medication group and the postprandial medication group. Methods: Three hundred patients were included in this study to determine their persistence and compliance with the prescribed daily BP (Maxmarvil®, alendronate 5 mg and calcitriol 0.5 μg; YuYu Pharm) following distal radius fractures. Patients in Group 1 (aperitif medication) were asked to adhere to the general guidelines for BPs before breakfast. Patients in Group 2 (postprandial medication) were recommended medication after breakfast. We compared the persistence and compliance of this daily BP therapy using the medication possession ratio (MPR) and T-scores between the 2 groups after 1 year. Results: Bone mineral density in hip and lumbar spine was improved significantly in 2 groups (P<0.001). Significant differences existed between 2 groups, including 73 of 150 patients (48.7%) in Group 1, and 111 of 150 patients (73.3%) in Group 2 for 1-year persistence (P=0.001). The mean MPR is 0.66 in Group 1 (range, 0.50-0.86) and 0.71 in Group 2 (range, 0.54-0.87). A significant difference was detected between the 2 groups (P=0.002). Conclusions: Postprandial administration improved persistence and compliance with daily BP therapy, resulting in better clinical outcomes.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Curtis JR / 2011 / The relationship between bisphosphonate adherence and fracture: is it the behavior or the medication? Results from the placebo arm of the fracture intervention trial / J Bone Miner Res 26:683~688
Ideguchi H / 2007 / Persistence with bisphosphonate therapy including treatment courses with multiple sequential bisphosphonates in the real world / Osteoporos Int 18:1421~1427
Cramer JA / 2008 / Medication compliance and persistence: terminology and definitions / Value Health 11:44~47
Briesacher BA / 2008 / Comparison of drug adherence rates among patients with seven different medical conditions / Pharmacotherapy 28:437~443
Curtis JR / 2008 / Benefit of adherence with bisphosphonates depends on age and fracture type: results from an analysis of 101,038 new bisphosphonate users / J Bone Miner Res 23:1435~1441
Ideguchi H / 2007 / Persistence with bisphosphonate therapy including treatment courses with multiple sequential bisphosphonates in the real world / Osteoporos Int 18:1421~1427
Cramer JA / 2008 / Medication compliance and persistence: terminology and definitions / Value Health 11:44~47
Briesacher BA / 2008 / Comparison of drug adherence rates among patients with seven different medical conditions / Pharmacotherapy 28:437~443
Curtis JR / 2008 / Benefit of adherence with bisphosphonates depends on age and fracture type: results from an analysis of 101,038 new bisphosphonate users / J Bone Miner Res 23:1435~1441
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