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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 740 - 748 (9page)
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초록· 키워드
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Background: Approximately 90%∼99% of ultraviolet A (UVA) ray reaches the Earth’s surface. The deeply penetrating UVA rays induce the formation of reactive oxygen species (ROS), which results in oxidative stress such as photoproducts, senescence, and cell death. Thus, UVA is considered a primary factor that promotes skin aging. Objective: Researchers investigated whether pretreatment with ferulic acid protects human dermal fibroblasts (HDFs) against UVA-induced cell damages. Methods: HDF proliferation was analyzed using the water-soluble tetrazolium salt assay.
Cell cycle distribution and intracellular ROS levels were assessed by flow cytometric analysis. Senescence was evaluated using a senescence-associated β-galactosidase assay, while Gadd45α promoter activity was analyzed through a luciferase assay. The expression levels of superoxide dismutase 1 (SOD1), catalase (CAT), xeroderma pigmentosum complementation group A and C, matrix metalloproteinase 1 and 3, as well as p21 and p16 were measured using quantitative real-time polymerase chain reaction. Results: Inhibition of proliferation and cell cycle arrest were detected in cells that were irradiated with UVA only. Pretreatment with ferulic acid significantly increased the proliferation and cell cycle progression in HDFs. Moreover, ferulic acid pretreatment produced antioxidant effects such as reduced DCF intensity, and affected SOD1 and CAT mRNA expression.
These effects were also demonstrated in the analysis of cell senescence, promoter activity, expression of senescent markers, and DNA repair. Conclusion: These results demonstrate that ferulic acid exerts protective effects on UVA-induced cell damages via anti-oxidant and stress-inducible cellular mechanisms in HDFs.
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참고문헌 (47)
참고문헌 신청
Jeong-Ju Lee / 2016 / Extract of Ettlia sp. YC001 Exerts Photoprotective Effects against UVB Irradiation in Normal Human Dermal Fibroblasts / Journal of Microbiology and Biotechnology 26(4):775~783
Faurschou A. / 2010 / Role of tumor necrosis factor-α in the regulation of keratinocyte cell cycle and DNA repair after ultraviolet-B radiation / Dan Med Bull 57:B4179
Bae S. / 2015 / Low-dose γ-irradiation induces dual radio-adaptive responses depending on the post-irradiation time by altering microRNA expression profiles in normal human dermal fibroblasts / Int J Mol Med 35:227~237
Bae S. / 2015 / Development of a high-throughput screening system for identification of novel reagents regulating DNA damage in human dermal fibroblasts / Acta Pharm 65:331~341
Mac-Mary S. / 2010 / Assessment of cumulative exposure to UVA through the study of asymmetrical facial skin aging / Clin Interv Aging 5:277~284
Faurschou A. / 2010 / Role of tumor necrosis factor-α in the regulation of keratinocyte cell cycle and DNA repair after ultraviolet-B radiation / Dan Med Bull 57:B4179
Bae S. / 2015 / Low-dose γ-irradiation induces dual radio-adaptive responses depending on the post-irradiation time by altering microRNA expression profiles in normal human dermal fibroblasts / Int J Mol Med 35:227~237
Bae S. / 2015 / Development of a high-throughput screening system for identification of novel reagents regulating DNA damage in human dermal fibroblasts / Acta Pharm 65:331~341
Mac-Mary S. / 2010 / Assessment of cumulative exposure to UVA through the study of asymmetrical facial skin aging / Clin Interv Aging 5:277~284
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