지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 286 - 295 (10page)
이용수
초록· 키워드
오류제보하기
Cellular replicative senescence is a major contributing factor to aging and to the development and progression of aging-associated diseases. In this study, we sought to determine viral replication efficiency of influenza virus (IFV) and Varicella Zoster Virus (VZV) infection in senescent cells. Primary human bronchial epithelial cells (HBE) or human dermal fibroblasts (HDF) were allowed to undergo numbers of passages to induce replicative senescence. Induction of replicative senescence in cells was validated by positive senescence-associated b-galactosidase staining. Increased susceptibility to both IFV and VZV infection was observed in senescent HBE and HDF cells, respectively, resulting in higher numbers of plaque formation, along with the upregulation of major viral antigen expression than that in the non-senescent cells. Interestingly, mRNA fold induction level of virus-induced type I interferon (IFN) was attenuated by senescence, whereas IFN-mediated antiviral effect remained robust and potent in virus-infected senescent cells. Additionally, we show that a longevity-promoting gene, sirtuin 1 (SIRT1), has antiviral role against influenza virus infection. In conclusion, our data indicate that enhanced viral replication by cellular senescence could be due to senescence-mediated reduction of virus-induced type I IFN expression.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (34)
참고문헌 신청
[학술지(정기간행물)] - van Deursen, J. M / 2014 / The role of senescent cells in ageing / Nature 509 : 439 ~ 446
[학술지(정기간행물)] - Hwang, E. S / 2002 / Replicative senescence and senescencelike state induced in cancer-derived cells / Mech. Ageing Dev 123 : 1681 ~ 1694
[학술지(정기간행물)] - Campisi, J / 1997 / The biology of replicative senescence / Eur. J. Cancer 33 : 703 ~ 709
[학술지(정기간행물)] - Dorrington, M. G / 2013 / Immunosenescence and novel vaccination strategies for the elderly / Front. Immunol 4 : 171 ~
[학술지(정기간행물)] - Reber, A. J / 2012 / Immunosenescence and challenges of vaccination against influenza in the aging population / Aging Dis 3 : 68 ~ 90
[학술지(정기간행물)] - Hwang, E. S / 2002 / Replicative senescence and senescencelike state induced in cancer-derived cells / Mech. Ageing Dev 123 : 1681 ~ 1694
[학술지(정기간행물)] - Campisi, J / 1997 / The biology of replicative senescence / Eur. J. Cancer 33 : 703 ~ 709
[학술지(정기간행물)] - Dorrington, M. G / 2013 / Immunosenescence and novel vaccination strategies for the elderly / Front. Immunol 4 : 171 ~
[학술지(정기간행물)] - Reber, A. J / 2012 / Immunosenescence and challenges of vaccination against influenza in the aging population / Aging Dis 3 : 68 ~ 90
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Regulation mechanism of mitochondria dynamics during cellular senescence: Is a promising target for aging?
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Induction of Nuclear Enlargement and Senescence by Sirtuin Inhibitors in Glioblastoma Cells
Immune Network
2016 .06
-
Luteolin inhibits H2O2-induced cellular senescence via modulation of SIRT1 and p53
The Korean Journal of Physiology & Pharmacology
2021 .01
-
Stereoisomer-specific ginsenoside 20(S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling
Journal of Ginseng Research
2020 .03
-
Proteomic analyses reveal that ginsenoside Rg3(S) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin
Journal of Ginseng Research
2020 .01
-
Rutaecarpine, Isolated from Evodia rutaecarpa, Inhibits Epithelial-Mesenchymal Transition and Cellular Senescence in a Mouse Model of Pulmonary Fibrosis
Natural Product Sciences
2024 .09
-
Effects of 5-Aza-2'-Deoxycytidine, Bromodeoxyuridine, Interferons and Hydrogen Peroxide on Cellular Senescence in Cholangiocarcinoma Cells
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
T-Cell Senescence in Human Metabolic Diseases
Diabetes and Metabolism Journal
2024 .09
-
Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway
The Korean Journal of Physiology & Pharmacology
2020 .01
-
Expression of Senescence-Associated Secretory Phenotype in Senescent Gingival Fibroblasts
치위생과학회지
2023 .06
-
Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Effect of High Glucose on Stress-Induced Senescence of Nucleus Pulposus Cells of Adult Rats
Asian Spine Journal
2015 .04
-
Comprehensive investigations of key mitochondrial metabolic changes in senescent human fibroblasts
The Korean Journal of Physiology & Pharmacology
2022 .07
-
Melatonin Rescues Human Dental Pulp Cells from Premature Senescence Induced by H2O2
International Journal of Oral Biology
2017 .01
-
Dual roles of Akt in induction and maturation of cellular senescence phenotype : A promising target for SASP control?
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Nrf2 Connects Cellular Autophagy and Vascular Senescence in Atherosclerosis: A Mini-Review
지질·동맥경화학회지
2024 .09
-
Synergistic Tumoricidal Effects of Alpha-Lipoic Acid and Radiotherapy on Human Breast Cancer Cells Via HMGB1
Cancer Research and Treatment
2021 .01
-
Korean Red ginseng prevents endothelial senescence by downregulating the HO-1/NF-κB/miRNA-155-5p/eNOS pathway
Journal of Ginseng Research
2021 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2017-517-001663415