지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 213 - 219 (7page)
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초록· 키워드
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Objectives: Based on data from Chinese and Indian traditional herbal medicines, gum resin of Ferula assa-foetida (sometimes referred to asafetida or asafoetida) has several therapeutic applications. The authors of various studies have claimed that asafetida has cytotoxic, antiulcer, anti-neoplasm, anti-cancer, and anti-oxidative effects. In present study, the anti-aging effect of asafetida on senescent human dermal fibroblasts was evaluated.
Methods: Senescence was induced in in vitro cultured human dermal fibroblasts (HDFs) through exposure to H2O2, and the incidence of senescence was recognized by using cytochemical staining for the activity of β-galactosidase. Then, treatment with oleo gum resin of asafetida was started to evaluate its rejuvenating effect. The survival rate of fibroblasts was evaluated by using methyl tetrazolium bromide (MTT) assays. Real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blot assays were performed to evaluate the expressions of apoptotic and anti-apoptotic markers. Results: Our experiments show that asafetida in concentrations ranging from 5 × 10-8 to 10-7 g/mL has revitalizing effects on senescent fibroblasts and significantly reduces the β-galactosidase activity in these cells (P < 0.05). Likewise, treatment at these concentrations increases the proliferation rate of normal fibroblasts (P < 0.05). However, at concentrations higher than 5 × 10-7 g/mL, asafetida is toxic for cells and induces cell death.
Conclusion: The results of this study indicate that asafetida at low concentrations has a rejuvenating effect on senescent fibroblasts whereas at higher concentrations, it has the opposite effect of facilitating cellular apoptosis and death.
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참고문헌 (23)
참고문헌 신청
[학술지(정기간행물
Burdette JE / 2002 / Black cohosh (Cimicifuga racemosa L.)protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isol
Dinis TC / 2002 / The apoprotein is the preferential target for peroxynitrite-induced LDL damage protection by dietary phenolic acids / Free Radic Res 36 (5) : 531 ~ 543
Ekor M / 2013 / The growing use of herbal medicines : issues relating to adverse reactions and challenges in monitoring safety / Front Pharmacol 4 : 177 ~
Ferguson LR / 2003 / Bacterial antimutagenesis by hydroxycinnamic acids from plant cell walls / Mutat Res 542 (1-2) : 49 ~ 58
Burdette JE / 2002 / Black cohosh (Cimicifuga racemosa L.)protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isol
Dinis TC / 2002 / The apoprotein is the preferential target for peroxynitrite-induced LDL damage protection by dietary phenolic acids / Free Radic Res 36 (5) : 531 ~ 543
Ekor M / 2013 / The growing use of herbal medicines : issues relating to adverse reactions and challenges in monitoring safety / Front Pharmacol 4 : 177 ~
Ferguson LR / 2003 / Bacterial antimutagenesis by hydroxycinnamic acids from plant cell walls / Mutat Res 542 (1-2) : 49 ~ 58
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