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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 150 - 157 (8page)
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초록· 키워드
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Background: Contact immune modulating therapy with diphenylcyclopropenone (DPCP) is a topical treatment option for extensive alopecia areata (AA). Because the response to DPCP treatment varies according to the patient, and it takes several months to evaluate the clinical effectiveness of the treatment, it is necessary to identify the factors that can predict the prognosis of the disease while treating with topical DPCP. Objective: In this study, cytokine levels in the scales of alopecic patches were investigated to identify whether they could predict response to DPCP during the early treatment period. Methods: Scale samples were taken from the alopecic patches in eight AA patients at 1 week, 2 months, and 4 months after DPCP sensitization. The patients were divided into responders and non-responders according to the clinical responses of DPCP treatment. Interferon (IFN)-gamma, interleukin (IL)-2, IL-12 and IL-10 levels of the subjects were compared in several perspectives. Results: Cytokine levels after 1 week of DPCP sensitization showed no statistically significant difference between two groups. After 4 months of treatment, IFN-gamma levels were significantly lower in responders than in non-responders. Conclusion: The results of this study show IFN-gamma levels in the scales of alopecic patches might possibly reflect the clinical response in AA patients treated with DPCP. However, initial cytokine levels could not predict the treatment response.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Gregoriou S / 2010 / Cytokines and other mediators in alopecia areata / Mediators Inflamm 2010:928030
박주희 / 2009 / 중증 원형탈모증에서 고용량 스테로이드 주기 요법과 Cyclosporine과 저용량 스테로이드 병합 요법의 비교 연구 / 대한피부과학회지 47(11):1220~1226
Fiedler-Weiss VC / 1987 / Evaluation of anthralin in the treatment of alopecia areata / Arch Dermatol 123:1491~1493
Mitchell AJ / 1985 / Topical photochemotherapy for alopecia areata / J Am Acad Dermatol 12:644~649
Berth-Jones J / 1994 / Diphencyprone is not detectable in serum or urine following topical application / Acta Derm Venereol 74:312~313
박주희 / 2009 / 중증 원형탈모증에서 고용량 스테로이드 주기 요법과 Cyclosporine과 저용량 스테로이드 병합 요법의 비교 연구 / 대한피부과학회지 47(11):1220~1226
Fiedler-Weiss VC / 1987 / Evaluation of anthralin in the treatment of alopecia areata / Arch Dermatol 123:1491~1493
Mitchell AJ / 1985 / Topical photochemotherapy for alopecia areata / J Am Acad Dermatol 12:644~649
Berth-Jones J / 1994 / Diphencyprone is not detectable in serum or urine following topical application / Acta Derm Venereol 74:312~313
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