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논문 기본 정보

자료유형
학술저널
저자정보
이영 (Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea.) 김경민 (Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea.) 유박린 (Department of Dermatology, Kyung Hee University School of Medicine, Seoul, Korea.) 허창훈 (Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.) 강훈 (Department of Dermatology, The Catholic University of Korea School of Medicine, Seoul, Korea.) 장용현 (Department of Dermatology, Kyungpook National University School of Medicine, Daegu, Korea.) 김도영 (Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.) 신현태 (Department of Dermatology, Inha University School of Medicine, Incheon, Korea.) 김문범 (Department of Dermatology, Pusan National University School of Medicine, Busan, Korea.) 박진 (Department of Dermatology, Jeonbuk National University Medical School, Jeonju, Korea.Research Institute of Clinical Medicine of Jeonbuk National University, Biomedical Research Institute of) 김민성 (Department of Dermatology, Chosun University College of Medicine, Gwangju, Korea.) 최광성 (Department of Dermatology, Inha University School of Medicine, Incheon, Korea.)
저널정보
대한피부과학회 Annals of Dermatology Annals of Dermatology Vol.36 No.4
발행연도
2024.8
수록면
225 - 230 (6page)
DOI
10.5021/ad.23.138

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Background: Contact immunotherapy using diphenylcyclopropenone (DPCP) is a recommended treatment for severe alopecia areata (AA); however, few clinical factors are known, and few stan- dardized application methods affecting therapeutic efficacy have been devised. Objective: To confirm the therapeutic response of DPCP immunotherapy in AA, first we analyze the factors influencing its outcome and patient satisfaction levels, after which we standardize the DPCP treatment method for better outcomes. Methods: We utilized a nationwide questionnaire-based sur vey to assess patient satisfaction and undertook a medical record review involving 412 patients currently undergoing treatment for DPCP. Results: The patients’ mean age was 36.4 years, and 27% of the cases were diagnosed as AA in childhood. Treatment response was higher when DPCP was used to treat the entire scalp, includ- ing subclinical lesions, and longer treatment durations and longer inter vals between treatments were associated with a better treatment response. Atopy (atopic dermatitis, allergic rhinitis and bronchial asthma), thyroid disorder, and extent of hair loss were all negatively correlated with the treatment response. However, there was no correlation between the treatment response and factors such as the age of onset, a family histor y of AA, nail changes, or AA duration, which are commonly known to be associated with a poor prognosis. Conclusion: DPCP immunotherapy is an effective treatment for AA, and the study demonstrated the factors affecting DPCP treatment response and patients’ satisfaction and may contribute to standardizing the DPCP treatment method for better outcomes.

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