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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 9 (9page)
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Background: This study was performed to assess serial cytokine changes and their clinical impact in children with cerebral palsy (CP) who received granulocyte-colony stimulating factor (G-CSF) followed by infusion of autologous mobilized peripheral blood mononuclear cells (mPBMCs). Methods: Peripheral blood (PB) samples were collected from 16 CP children at enrollment, and 1 month and 7 months after G-CSF infusion as well as at the end of the study. Cytokine levels were measured by enzyme-linked immunosorbent assays with plasma samples. Results: There were no significant differences in cytokine levels between the mPBMC and placebo groups over 6 months. However, when clinical responders and non-responders were compared, interleukin (IL)-6 (P = 0.050) as well as G-CSF (P = 0.010) were higher in the responders than the non-responders at 1 month, while brain-derived neurotrophic factor (BDNF) (P = 0.030) and insulin-like growth factor (IGF)-1 (P = 0.001) were lower. In addition, BDNF was higher at baseline in the responders than the non-responders (P = 0.030). Conclusion: The changes of G-CSF itself, as well as G-CSF-induced cytokines such as IL-6, may be associated with the clinical improvement of neurologic functions. The G-CSF- induced changes of IL-6, BDNF and IGF-1, and BDNF levels before treatment, could be used as prognostic factors in G-CSF trials in CP children.
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참고문헌 (36)
참고문헌 신청
Caplan AI / 2006 / Mesenchymal stem cells as trophic mediators / J Cell Biochem 98(5):1076~1084
Mezey E / 2007 / Bone marrow-derived stem cells in neurological diseases: stones or masons? / Regen Med 2(1):37~49
Uccelli A / 2011 / Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases / Lancet Neurol 10(7):649~656
Oh YS / 2016 / Functional restoration of amyotrophic lateral sclerosis patient-derived mesenchymal stromal cells through inhibition of DNA methyltransferase / Cell Mol Neurobiol 36(4):613~620
Lu D / 2011 / Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: a double-blind, randomized, controlled trial / Diabetes Res Clin Pract 92(1):26~36
Mezey E / 2007 / Bone marrow-derived stem cells in neurological diseases: stones or masons? / Regen Med 2(1):37~49
Uccelli A / 2011 / Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases / Lancet Neurol 10(7):649~656
Oh YS / 2016 / Functional restoration of amyotrophic lateral sclerosis patient-derived mesenchymal stromal cells through inhibition of DNA methyltransferase / Cell Mol Neurobiol 36(4):613~620
Lu D / 2011 / Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: a double-blind, randomized, controlled trial / Diabetes Res Clin Pract 92(1):26~36
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