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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 193 - 199 (7page)
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Background Aplastic anemia (AA), an unusual hematological disease, is characterized by hypoplasia of the bone marrow and failure to form blood cells of all three lineages resulting in pancytopenia. This study aimed to investigate TNF--308 and IFN--874 gene polymorphisms and their respective plasma protein levels in patients with AA and healthy controls. Methods Two hundred and forty individuals were included in this study; the case group comprised 120 AA patients, while 120 healthy individuals served as controls. Genotyping was performed using the PCR-restriction length fragment polymorphism method and TNF--308 and IFN--874 plasma levels were evaluated using an ELISA kit. Results There was a significantly higher prevalence of the IFN--874 genotype in patients with AA than in healthy controls, while the TNF--308 genotype was associated with lower risk of developing AA. Furthermore, the levels of both TNF--308 and IFN--874 were higher in the plasma of AA patients. Conclusion Our findings suggest that the IFN--874 genotype may be a greater risk factor in the causation of AA, whereas the TNF--308 genotype has a protective role in the North Indian population.
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참고문헌 (24)
참고문헌 신청
Dezern AE / 2011 / Clinical management of aplastic anemia / Expert Rev Hematol 4:221~230
Issaragrisil S / 2006 / The epidemiology of aplastic anemia in Thailand / Blood 107:1299~1307
Cuglievan B / 2016 / Aplastic anemia : the correct nomenclature matters / Haematologica 101:e391
Malhotra P / 2016 / High incidence of aplastic anemia is linked with lower socioeconomic status of Indian population / J Public Health(Oxf) 38:223~228
Shallis RM / 2018 / Aplastic anemia : etiology, molecular pathogenesis, and emerging concepts / Eur J Haematol 101:711~720
Issaragrisil S / 2006 / The epidemiology of aplastic anemia in Thailand / Blood 107:1299~1307
Cuglievan B / 2016 / Aplastic anemia : the correct nomenclature matters / Haematologica 101:e391
Malhotra P / 2016 / High incidence of aplastic anemia is linked with lower socioeconomic status of Indian population / J Public Health(Oxf) 38:223~228
Shallis RM / 2018 / Aplastic anemia : etiology, molecular pathogenesis, and emerging concepts / Eur J Haematol 101:711~720
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