지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 113 - 121 (9page)
이용수
DBpia Top 5%동일한 주제분류 기준으로최근 2년간 이용수 순으로 정렬했을 때
해당 논문이 위치하는 상위 비율을 의미합니다.
초록· 키워드
오류제보하기
Objectives：This study aimed to identify factors associated with patients’ improved scores on the Mini Mental State Examination(MMSE) improvement by comparing the total MMSE scores of patients with Alzheimer’s disease(AD) before and after acetylcholinesterase inhibitors(AChEIs) treatment.
Methods：Data from fifty-three outpatients with AD were analyzed in this retrospective study. The patients received AChEIs and were assessed using cognitive function tests two times at 12-month intervals. The cognitive function assessments included the Clinical Dementia Rating(CDR) and neuropsychological tests of the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease(CERAD-K). Patients were assessed for depressive symptoms using a Revised Korean version of the Geriatric Depression Scale(GDS-KR). The patients with improved MMSE scores comprised the Responder group, whereas the patients with deteriorated or unimproved MMSE scores comprised the Non?Responder group. The demographic and neuropsychological factors between the two groups were analyzed using the Chi-square test, t-test and Mann-Whitney test. The paired t-test and Wilcoxon signed-rank test were used for comparing clinical responses within each group.
Results：Seventeen patients were included in the Responder group and thirty-six patients were included in the Non?Responder group. The baseline GDS-KR scores were significantly higher in the Responder group than in the Non-Responder group(p=0.018). The GDS-KR scores significantly decreased in the Responder group after 12 months(p=0.048). There was no difference between the two groups across cognitive subdomains.
Conclusion：This study suggests that cognitive improvement following AChEIs for AD is associated with the response of depressive symptoms.
Methods：Data from fifty-three outpatients with AD were analyzed in this retrospective study. The patients received AChEIs and were assessed using cognitive function tests two times at 12-month intervals. The cognitive function assessments included the Clinical Dementia Rating(CDR) and neuropsychological tests of the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease(CERAD-K). Patients were assessed for depressive symptoms using a Revised Korean version of the Geriatric Depression Scale(GDS-KR). The patients with improved MMSE scores comprised the Responder group, whereas the patients with deteriorated or unimproved MMSE scores comprised the Non?Responder group. The demographic and neuropsychological factors between the two groups were analyzed using the Chi-square test, t-test and Mann-Whitney test. The paired t-test and Wilcoxon signed-rank test were used for comparing clinical responses within each group.
Results：Seventeen patients were included in the Responder group and thirty-six patients were included in the Non?Responder group. The baseline GDS-KR scores were significantly higher in the Responder group than in the Non-Responder group(p=0.018). The GDS-KR scores significantly decreased in the Responder group after 12 months(p=0.048). There was no difference between the two groups across cognitive subdomains.
Conclusion：This study suggests that cognitive improvement following AChEIs for AD is associated with the response of depressive symptoms.
목차
서론
대상 및 방법
결과
고찰
참고문헌
참고문헌 (43)
참고문헌 신청
[학술지(정기간행물)] - Fratiglioni L / 1991 / Prevalence of Alzheimer's disease and other dementias in an elderly urban population: Relationship with age, sex, and education / Neurology 41 : 1886 ~ 1892
[학술지(정기간행물)] - Selkoe DJ / 2004 / Cell biology of protein misfolding: The examples of Alzheimer’s and Parkinson’s diseases / Nat Cell Biol 6 : 1054 ~ 1061
[학술지(정기간행물)] - Francis PT / 1999 / The cholinergic hypothesis of Alzheimer’s disease: A review of progress / J Neurol Neurosurg Psychiatry 66 : 137 ~ 147
[학술지(정기간행물)] - Bullock R / 2002 / New drugs for Alzheimer’s disease and other dementias / Br J Psychiatry 180 : 135 ~ 139
[학술지(정기간행물)] - Lanctôt KL / 2003 / Efficacy and safety of cholinesterase inhibitors in Alzheimer’s disease: a meta-analysis / CMAJ 169 : 557 ~ 564
[학술지(정기간행물)] - Selkoe DJ / 2004 / Cell biology of protein misfolding: The examples of Alzheimer’s and Parkinson’s diseases / Nat Cell Biol 6 : 1054 ~ 1061
[학술지(정기간행물)] - Francis PT / 1999 / The cholinergic hypothesis of Alzheimer’s disease: A review of progress / J Neurol Neurosurg Psychiatry 66 : 137 ~ 147
[학술지(정기간행물)] - Bullock R / 2002 / New drugs for Alzheimer’s disease and other dementias / Br J Psychiatry 180 : 135 ~ 139
[학술지(정기간행물)] - Lanctôt KL / 2003 / Efficacy and safety of cholinesterase inhibitors in Alzheimer’s disease: a meta-analysis / CMAJ 169 : 557 ~ 564
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Behavioral Effects of Combination Therapy of Memantine and Acetylcholinesterase Inhibitors Compared with Acetylcholinesterase Inhibitors Alone in Patients with Moderate Alzheimer’s Dementia: A Double-Blind Randomized Placebo-Controlled Trial
PSYCHIATRY INVESTIGATION
2021 .01
-
Longitudinal Assessment of Intravoxel Incoherent Motion Diffusion Weighted Imaging in Evaluating the Radio-sensitivity of Nasopharyngeal Carcinoma Treated with Intensity-Modulated Radiation Therapy
Cancer Research and Treatment
2019 .01
-
Neuropsychological Outcome One Year after Carotid Revascularization: A before-and-after Study
Vascular Specialist International
2017 .01
-
Echocardiographic, Electrocardiographic Changes and Clinical Outcomes of Patients Who Respond to Cardiac Resynchronization Therapy after One Year
Journal of Cardiovascular Imaging
2017 .01
-
Incidence and Course of Depression in Patients with Alzheimer’s Disease
PSYCHIATRY INVESTIGATION
2017 .01
-
알츠하이머병과 경도인지장애에서 체질량지수와 인지기능과의 연관성
정신신체의학
2016 .01
-
지역사회 거주 노인의 인지기능과 우울증상 사이의 상관성 분석
노인정신의학
2021 .01
-
The Relationship between Geriatric Depression Scale Structure and Cognitive-Behavioral Aspects in Patients with Alzheimer’s Disease
Dementia and Neurocognitive Disorders(대한치매학회지)
2015 .01
-
The Effect of Cognitive Training in a Day Care Center in Patients with Early Alzheimer’s Disease Dementia: A Retrospective Study
PSYCHIATRY INVESTIGATION
2020 .01
-
Redefining the Positive Circumferential Resection Margin by Incorporating Preoperative Chemoradiotherapy Treatment Response in Locally Advanced Rectal Cancer: A Multicenter Validation Study
Cancer Research and Treatment
2018 .01
-
알츠하이머병과 경도인지장애에서 헤모글로빈 농도와 인지기능과의 연관성
정신신체의학
2016 .01
-
Simvastatin/Ezetimibe Therapy for Recalcitrant Alopecia Areata: An Open Prospective Study of 14 Patients
Annals of Dermatology
2017 .01
-
Single Photon Emission Computerized Tomography and Neuropsychological Tests That Predict a Good Response to Donepezil Therapy for Alzheimer’s Disease
Dementia and Neurocognitive Disorders(대한치매학회지)
2015 .01
-
The Impact of the COVID-19 Pandemic and Social Distancing on Cognition of Alzheimer’s Disease Patients
PSYCHIATRY INVESTIGATION
2022 .11
-
The Neuropsychological Characteristics in Early Stage of Alzheimer’s Patients with Depression
Dementia and Neurocognitive Disorders(대한치매학회지)
2016 .01
-
Clinical Characteristics and Metabolic Predictors of Rapid Responders to Dipeptidyl Peptidase-4 Inhibitor as an Add-on Therapy to Sulfonylurea and Metformin
Diabetes and Metabolism Journal
2015 .01
-
Cardiovascular Complications of Acetylcholinesterase Inhibitors in Patients with Alzheimer’s Disease: A Narrative Review
Annals of geriatric medicine and research
2021 .09
-
The Association of Blood-Based Inflammatory Factors IL-1β, TGF-β and CRP with Cognitive Function in Alzheimer’s Disease and Mild Cognitive Impairment
PSYCHIATRY INVESTIGATION
2021 .01
-
Is the Korean Mini-Mental State Examination (K-MMSE) Useful in Evaluating the Cognitive Function of Brain Injury Patients?: Through Correlation Analysis With Computerized Neurocognitive Test (CNT)
뇌신경재활
2024 .07
-
Effect of Integrated Cognitive Intervention Therapy in Patients with Mild to Moderate Alzheimer's Disease
Dementia and Neurocognitive Disorders(대한치매학회지)
2020 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
다시 보는 알츠하이머병의 아밀로이드 가설
김병수
생물치료정신의학
2014
.12
노인성 우울증과 알츠하이머병의 관계 : 아밀로이드 이론을 바탕으로
김혜금
,
천은진
,
구본훈
생물치료정신의학
2016
.02
알츠하이머병과 영양 생체지표
강희주
,
홍종우
,
한지원
외 6명
생물치료정신의학
2014
.12
알츠하이머형 치매에서 Memantine 투여가 혈청 Total Antioxidant Capacity에 미치는 영향
전진숙
,
김인성
,
오병훈
생물치료정신의학
2007
.06
알츠하이머 치매 환자에서 치료 전 중증도에 따른 약물의 장기 치료 효과
서희원
,
박유리
,
권인선
외 1명
생물치료정신의학
2021
.02
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-513-001657519