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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Juan Pablo Sosa (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Maria Mercedes Ferreira Caceres (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Jennifer Ross Comptis (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Jorge Quiros (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Fortunato S Principe-Meneses (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Riva-Moscoso Adrian (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Marie-Pierre Belizaire (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Freda Q. Malanyaon (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Kuchalambal Agadi (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Syeda Sheharbano Jaffery (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Juhi Sahajwani (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Asma Arshia (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Andrelle Senatus (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Graciela Verdecia (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Lordstrong Akano (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Aminah Abdul Razzack (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Sanna Salam (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Vinay Kumar Gadamidi (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.) Sheeba Marian (Division of Research & Academic Affairs Larkin Health System South Miami FL USA.)
저널정보
대한감염학회 Infection and Chemotherapy Infection and Chemotherapy 제53권 제2호
발행연도
2021.1
수록면
247 - 260 (14page)

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Background The high rate of transmission and infection of coronavirus disease 2019 (COVID-19) is a public health emergency of major epidemiological concern. No definitive treatments have been established, and vaccinations have only recently begun. We aim to review the efficacy and safety of Interferon Beta (IFN-β) in patients who have a confirmed COVID-19 diagnosis. Materials and Methods A search from PubMed, Science Direct, Cochrane, and Clinicaltrials.gov databases were conducted from December 2019 to December 2020 to review the efficacy and safety of IFN-β in adult patients with COVID-19 confirmed. We included randomized controlled trials, case reports, and experimental studies. Correspondences, letters, editorials, reviews, commentaries, case control, cross-sectional, and cohort studies that did not include any new clinical data were excluded. Results Of the 66 searched studies, 8 were included in our review. These studies demonstrated that although IFN-β did not reduce the time to clinical response, there was an increase in discharge rate at day 14 and a decrease in mortality at day 28. The time to negative reverse transcription polymerase chain reaction (RT-PCR) was shown to be significantly shortened in patients receiving IFN-β, along with a lower nasopharyngeal viral load. Further, patients receiving IFN-β had a less significant rise in IL-6. IFN-β was shown to decrease intensive care unit (ICU) admission rate, the requirement of invasive ventilation in severe cases, and improve the survival rate compared to control groups. There were no severe adverse events reported. Our review found that patients who received early treatment with IFN-β experienced significantly reduced length of hospitalization, mortality, ICU admission, and mechanical ventilation. A greater chance of clinical improvement and improved imaging studies was noted in patients who received IFN-β. There were no reported deaths associated with the addition of IFN-β. Further randomized trials involving more significant sample sizes are needed to better understand the effect of IFN-β on survival in COVID-19. Conclusion This review identified encouraging data and outcomes of incorporating IFN-β to treat COVID-19 patients. IFN-β has been shown to decrease hospital stay's overall length and decrease the severity of respiratory symptoms when added to the standard of care. Also, in some studies, it has been demonstrated to reduce the length of ICU stay, enhance survival rate, and decrease the need for invasive mechanical ventilation. There were minor side effects reported (neuropsychiatric symptoms and hypersensitivity reaction). However, randomized clinical trials with a large sample size are needed to assess IFN-β's benefit precisely.
#COVID-19 #SARS-CoV-2 #Coronavirus #Interferon beta #Beta-Interferon

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참고문헌 (32)

참고문헌 신청
World Health Organization (WHO) / Weekly epidemiological update - 27 January 2021 google schola Chen Y / 2020 / Emerging coronaviruses: Genome structure, replication, and pathogenesis / J Med Virol 92 google schola Wu C / 2020 / Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods / Acta Pharm Sin B 10:766~788 google schola Kumar M / 2020 / Pathophysiology and treatment strategies for COVID-19 / J Transl Med 18:353 google schola Zumla A / 2016 / Coronaviruses - drug discovery and therapeutic options / Nat Rev Drug Discov 15:327~347 google schola

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