지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 509 - 517 (9page)
이용수
초록· 키워드
오류제보하기
Purpose The Notch signaling pathway is widely expressed in normal, reactive, and neoplastic tissues; however, its role in thyroid tissues has not been fully elucidated. Therefore, this study was conducted to characterize the expression of the Notch signaling pathway in papillary thyroid cancer (PTC) cells and anaplastic thyroid cancer (ATC) cells.
Materials and Methods Expression of activated Notch1 in ATC and PTC paraffin-embedded tissues was determined by immunohistochemistry. The small interfering RNA technique was employed to knock down Notch1 expression in ATC and PTC cell lines.
Results The expression of activated Notch1 was higher in ATC cases than in PTC cases. Inhibition of Notch1 significantly reduced proliferation and migration of ATC cells, but not PTC cells.
In addition, inhibition of Notch1 in ATC cells significantly reduced the expression of key markers of epithelial-mesenchymal transition and cancer stem cells. Conversely, changes in the expression of these proteins were not observed in PTC cells.
Conclusion The results of this study suggest that Notch1 expression plays different roles in tumor progression in ATC and PTC cells. We also found that Notch1 expression was significantly related to the highly invasive or proliferative activity of ATC cells.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
[
Bao B / 2011 / Notch-1induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells / Cancer Lett 307 : 26 ~ 36
Bray SJ / 2006 / Notch signalling : a simple pathway becomes complex / Nat Rev Mol Cell Biol 7 : 678 ~ 689
Cao YW / 2015 / Implications of the Notch1-Snail/Slug-epithelial to mesenchymal transition axis for lymph node metastasis in infiltrating ductal carcinoma / Kaohsiung J Med
Chen W / 2015 / Notch-1 knockdown suppresses proliferation, migration and metastasis of salivary adenoid cystic carcinoma cells / J Transl Med 13 : 167 ~
Bao B / 2011 / Notch-1induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells / Cancer Lett 307 : 26 ~ 36
Bray SJ / 2006 / Notch signalling : a simple pathway becomes complex / Nat Rev Mol Cell Biol 7 : 678 ~ 689
Cao YW / 2015 / Implications of the Notch1-Snail/Slug-epithelial to mesenchymal transition axis for lymph node metastasis in infiltrating ductal carcinoma / Kaohsiung J Med
Chen W / 2015 / Notch-1 knockdown suppresses proliferation, migration and metastasis of salivary adenoid cystic carcinoma cells / J Transl Med 13 : 167 ~
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Coexistent Papillary Thyroid Carcinoma and Its Anaplastic Transformation in Cervical Lymph Node Metastasis
International Journal of Thyroidology
2020 .01
-
Importance of Regular Follow-Up Examination during Active Surveillance: a Case of Anaplastic Transformation of Papillary Thyroid Microcarcinoma
International Journal of Thyroidology
2016 .01
-
Rare Manifestations of Anaplastic Thyroid Carcinoma: the Role of BRAF Mutation Analysis
Journal of Korean Medical Science
2017 .01
-
갑상선 유두상 암의 경부 림프절 전이에서 발생한 갑상선 역형성 암
임상이비인후과
2018 .01
-
The Significance of NOTCH Pathway in the Development of Fibrosis in Systemic Sclerosis
Annals of Dermatology
2019 .01
-
Nerve Growth Factor Stimulates Glioblastoma Proliferation through Notch1 Receptor Signaling
대한신경외과학회지
2018 .01
-
Ultrasonographic imaging of papillary thyroid carcinoma variants
ULTRASONOGRAPHY
2017 .01
-
Notch1 in Tumor Microvascular Endothelial Cells and Tumoral miR-34a as Prognostic Markers in Locally Advanced Triple-Negative Breast Cancer
Journal of Breast Cancer
2019 .01
-
Clinical Characteristics and Prognosis of Differentiated Thyroid Carcinoma with Small Foci of Anaplastic Transformation
International Journal of Thyroidology
2017 .01
-
A Case of Occult Anaplastic Thyroid Cancer Presenting as Huge Renal Mass
대한이비인후-두경부외과학회지
2021 .09
-
Cohexisting Medullary and Papillary Thyroid Cancer
The Journal of Endocrine Surgery
2017 .01
-
Proto-oncogene Pokemon in thyroid cancer: a potential promoter of tumorigenesis in papillary thyroid carcinoma
Journal of Pathology and Translational Medicine
2021 .09
-
Outcomes of scapular notching
대한견주관절의학회 학술대회논문집
2022 .11
-
Prognostic Significance of Hes-1, a Downstream Target of Notch Signaling in Hepatocellular Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
MiR-99a Inhibits Cell Proliferation and Tumorigenesis through Targeting mTOR in Human Anaplastic Thyroid Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Mean Platelet Volume Could be a Possible Biomarker for Papillary Thyroid Carcinomas
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Do Helper T Cell Subtypes in Lymphocytic Thyroiditis Play a Role in the Antitumor Effect?
Journal of Pathology and Translational Medicine
2016 .01
-
Interaction of Wnt5a with Notch1 is Critical for the Pathogenesis of Psoriasis
Annals of Dermatology
2016 .01
-
Management of Low-Risk Papillary Thyroid Cancer
Endocrinology and Metabolism
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0