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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 645 - 652 (8page)
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초록· 키워드
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Background: Adiponectin, an adipokine secreted from adipocytes, affects energy metabolism and also shows anti-diabetic and anti-inflammatory properties. Recent studies have reported that adiponectin plays a role in regulating skin inflammation. Objective: This study aimed to investigate the effect of adiponectin on the expression of filaggrin (FLG) in normal human epidermal keratinocytes (NHEKs). Methods: NHEKs were serum-starved for 6h before being treated with adiponectin. Afterward, cell viability was assessed by MTT assay. We also treated with calcium, interleukin (IL)-4, and IL-13 to provide positive and negative comparative controls, respectively. Gene mRNA expression was quantified using real time reverse transcription polymerase chain reaction, and protein expression was evaluated using Western blot. To evaluate the relationship among mitogen-activated protein kinases (MAPKs), activator protein 1 (AP-1), and FLG, we also treated cells with inhibitors for MAPKs JNK, p38, and ERK1/2. Results: FLG and FLG-2 mRNA expression in NHEKs significantly increased after treatment with 10 μg/ml adiponectin. Adiponectin also restored FLG and FLG-2 mRNA expression that was otherwise inhibited by treatment with IL-4 and IL-13. Adiponectin induced FLG expression via AP-1 and MAPK signaling. Conclusion: Adiponectin positively regulated the expression of FLG and could be useful as a therapeutic agent to control diseases related to disrupted skin barrier function.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Scherer PE / 1995 / A novel serum protein similar to C1q, produced exclusively in adipocytes / J Biol Chem 270:26746~26749
Weyer C / 2001 / Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia / J Clin Endocrinol Metab 86:1930~1935
Weiss R / 2005 / The "obese insulin-sensitive" adolescent:importance of adiponectin and lipid partitioning / J Clin Endocrinol Metab 90:3731~3737
Goldstein BJ / 2004 / Adiponectin: a novel adipokine linking adipocytes and vascular function / J Clin Endocrinol Metab 89:2563~2568
Magge SN / 2011 / Adiponectin is associated with favorable lipoprotein profile, independent of BMI and insulin resistance, in adolescents / J Clin Endocrinol Metab 96:1549~1554
Weyer C / 2001 / Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia / J Clin Endocrinol Metab 86:1930~1935
Weiss R / 2005 / The "obese insulin-sensitive" adolescent:importance of adiponectin and lipid partitioning / J Clin Endocrinol Metab 90:3731~3737
Goldstein BJ / 2004 / Adiponectin: a novel adipokine linking adipocytes and vascular function / J Clin Endocrinol Metab 89:2563~2568
Magge SN / 2011 / Adiponectin is associated with favorable lipoprotein profile, independent of BMI and insulin resistance, in adolescents / J Clin Endocrinol Metab 96:1549~1554
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