지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 407 - 413 (7page)
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초록· 키워드
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Background: Filaggrin (FLG) is the major component of the epidermal granular layer and binds to and condenses the keratin cytoskeleton. FLG thus contributes to cell compaction and serves as a natural moisturizing factor by promoting unfolding and degradation into hygroscopic amino acids. Loss or downregulation of FLG has been shown to result in a weak stratum corneum, which causes water loss and increases the possibility of skin barrier-related seizure. Adiponectin (Acrp30) contributes to the functional recovery of somatic cells, including human normal epidermal keratinocytes (NHEKs). Objective: To investigate the effect of Acrp30 in FLG expression and identifying its signal transduction mechanism. Methods: Normal human keratinocytes were treated with Acrp30 and the levels of FLG were examined.
Silent mating type information regulation 2 homolog (SIRT)-targeting siRNA and aryl hydrocarbon receptor nuclear translocator (ARNT)-targeting siRNA were used to identify the role of various signal transduction pathway components. Results: Acrp30 upregulated SIRT1 and ARNT expression in NHEKs, resulting in increased FLG expression.
Treatment with both SIRT1-targeting siRNA and ARNT-targeting siRNA blocked Acrp30 stimulation and silenced FLG expression. Conclusion: Adiponectin upregulates FLG expression through a SIRT1-mediated pathway. Our results suggest that Acrp30 is a promising agent for skin barrier permeability improvement.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Blander G / 2009 / SIRT1 promotes differentiation of normal human keratinocytes / J Invest Dermatol 129 : 41 ~ 49
Canto C / 2009 / AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity / Nature 458 : 1056 ~ 1060
Chaudhary N / 2009 / Metabolic benefits from Sirt1 and Sirt1 activators / Curr Opin Clin Nutr Metab Care 12 : 431 ~ 437
Costa Cdos S / 2011 / Resveratrol upregulated SIRT1, FOXO1, and adiponectin and downregulated PPARγ1-3mRNA expression in human visceral adipocytes / Obes Surg 21 : 356 ~ 36
Denison MS / 2003 / Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals / Annu Rev Pharmacol Toxicol 43 : 309 ~ 334
Canto C / 2009 / AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity / Nature 458 : 1056 ~ 1060
Chaudhary N / 2009 / Metabolic benefits from Sirt1 and Sirt1 activators / Curr Opin Clin Nutr Metab Care 12 : 431 ~ 437
Costa Cdos S / 2011 / Resveratrol upregulated SIRT1, FOXO1, and adiponectin and downregulated PPARγ1-3mRNA expression in human visceral adipocytes / Obes Surg 21 : 356 ~ 36
Denison MS / 2003 / Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals / Annu Rev Pharmacol Toxicol 43 : 309 ~ 334
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