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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제22권 제5호
- 발행연도
- 2019.1
- 수록면
- 470 - 478 (9page)
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Purpose: The incidence of non-alcoholic fatty liver disease (NAFLD) in children is gradually increasing. The aim of this study was to investigate the use of serum adiponectin and soluble adiponectin receptor 2 (soluble Adipo R2) levels for the diagnosis of fatty liver disease in obese and overweight children. Methods: The study included 51 obese and overweight children between the ages of 6 and 18 years diagnosed with NAFLD using ultrasonography and 20 children without fatty liver disease. Patients whose alanine transaminase level was two times higher than normal (≥80 U/L) were included in the non-alcoholic steatohepatitis (NASH) group. Results: NASH was observed in 11 (21.6%) of the patients with NAFLD. The incidence of obesity was higher in patients with NASH (80% and 45%, p=0.021). While the adiponectin levels were similar in patients with NAFLD and those without, they were below the normal level in the whole study group. Adiponectin and soluble Adipo R2 levels of patients with NASH were lower than those in patients without NASH; however, this difference was not statistically significant (p=0.064 and p=0.463). Soluble Adipo R2 levels in obese patients with NAFLD were higher than those in obese children without NAFLD (p<0.001). Conclusion: Soluble adiponectin receptor 2 level is a noninvasive marker that can be used for the diagnosis of NAFLD in obese children.
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참고문헌 (31)
참고문헌 신청
Lavine JE / 2004 / Nonalcoholic fatty liver disease in the pediatric population / Clin Liver Dis 8:549~558
Angulo P / 2002 / Nonalcoholic fatty liver disease / N Engl J Med 346:1221~1231
Roberts EA / 2007 / Pediatric nonalcoholic fatty liver disease(NAFLD) : a"growing"problem? / J Hepatol 46:1133~1142
Clemente MG / 2016 / Pediatric non-alcoholic fatty liver disease : recent solutions, unresolved issues, and future research directions / World J Gastroenterol 22:8078~8093
Anderson EL / 2015 / The prevalence of non-alcoholic fatty liver disease in children and adolescents : a systematic review and meta-analysis / PLoS One 10:e0140908
Angulo P / 2002 / Nonalcoholic fatty liver disease / N Engl J Med 346:1221~1231
Roberts EA / 2007 / Pediatric nonalcoholic fatty liver disease(NAFLD) : a"growing"problem? / J Hepatol 46:1133~1142
Clemente MG / 2016 / Pediatric non-alcoholic fatty liver disease : recent solutions, unresolved issues, and future research directions / World J Gastroenterol 22:8078~8093
Anderson EL / 2015 / The prevalence of non-alcoholic fatty liver disease in children and adolescents : a systematic review and meta-analysis / PLoS One 10:e0140908
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