지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 395 - 400 (6page)
이용수
초록· 키워드
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Purpose: Atopic dermatitis (AD) is a chronic, relapsing eczematous inflammatory skin disease. Mutations in the filaggrin gene (FLG) are major predisposing factors for AD. Ethnic differences exist between Asian and European populations in the frequency and spectrumof FLG mutations. Moreover, a distinct set of FLG mutations has been reported in Asian populations. The aim of this study was to examine the spectrum of FLG mutations in Koreans with AD. We also investigated the association of FLG mutations and clinical features of AD and compared the Korean FLG landscape with that of other East Asian countries.
Materials and Methods: Seventy Korean patients with AD were enrolled in this study. Fourteen FLG mutations previously detected in Korean, Japanese, and Chinese patients were screened by genotyping.
Results: Four FLG null mutations (3321delA, K4022X, S3296X, and S2889X) were identified in eleven patients (15.7%). The most commonly detected mutations in Korean patients with AD were 3321delA (n=6, 9.1%) and K4022X (n=3, 4.5%). FLG mutations were significantly associated with elevated IgE (≥200 KIU/L and/or MAST-CLA >3+, p=0.005), palmar hyperlinearity (p<0.001), and a familyhistory of allergic disease (p=0.021).
Conclusion: This study expanded our understanding of the landscape of FLG mutations in Koreans and revealed an association betweenFLG mutations and AD phenotype.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
/ 1993 / Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis / Dermatology 186 : 23 ~ 31
Akiyama M / 2010 / FLG mutations in ichthyosis vulgaris and atopic eczema:spectrum of mutations and population genetics / Br J Dermatol 162 : 472 ~ 477
Bieber T / 2008 / Atopic dermatitis / N Engl J Med 358 : 1483 ~ 1494
Dale BA / 1977 / Purification and characterization of a basic protein from the stratum corneum of mammalian epidermis / Biochim Biophys Acta 491 : 193 ~ 204
Eun Joo Kim / 2011 / Genetic Polymorphism of FLG in Korean Ichthyosis Vulgaris Patients / Annals of Dermatology 23 (2) : 170 ~ 176
Akiyama M / 2010 / FLG mutations in ichthyosis vulgaris and atopic eczema:spectrum of mutations and population genetics / Br J Dermatol 162 : 472 ~ 477
Bieber T / 2008 / Atopic dermatitis / N Engl J Med 358 : 1483 ~ 1494
Dale BA / 1977 / Purification and characterization of a basic protein from the stratum corneum of mammalian epidermis / Biochim Biophys Acta 491 : 193 ~ 204
Eun Joo Kim / 2011 / Genetic Polymorphism of FLG in Korean Ichthyosis Vulgaris Patients / Annals of Dermatology 23 (2) : 170 ~ 176
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