지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background: Oxidative stress occurs in white adipose tissue and dysregulates the expression of adipokines secreted from adipocytes. Since adipokines influence inflammation, supplementation with antioxidants might be beneficial for preventing oxidative stress-mediated inflammation in adipocytes and inflammation-associated complications. β-Carotene is the most prominent antioxidant carotenoid and scavenges reactive oxygen species in various tissues. The purpose of this study was to determine whether -carotene regulates the expression of adipokines, such as adiponectin, monocyte chemoattractant protein-1 (MCP-1), and regulated on activation, normal T cell expressed and secreted (RANTES) in 3T3-L1 adipocytes treated with glucose/glucose oxidase (G/GO). Methods: 3T3-L1 adipocytes were cultured with or without β-carotene and treated with G/GO, which produces H2O2. mRNA and protein levels in the medium were determined by a real-time PCR and an ELISA. DNA binding activities of transcription factors were assessed using an electrophoretic mobility shift assay. Results: G/GO treatment increased DNA binding affinities of redox-sensitive transcription factors, such as NF-kB, activator protein-1 (AP-1), and STAT3. G/GO treatment reduced the expression of adiponectin and increased the expression of MCP-1 and RANTES. G/GO-induced activations of NF-kB, AP-1, and STAT3 were inhibited by β-carotene. G/GO-induced dysregulation of adiponectin, MCP-1, and RANTES were significantly recovered by treatment with β-carotene. Conclusions: β-Carotene inhibits oxidative stress-induced inflammation by suppressing pro-inflammatory adipokines MCP-1 and RANTES, and by enhancing adiponectin in adipocytes. β-Carotene may be beneficial for preventing oxidative stress-mediated inflammation, which is related to adipokine dysfunction. (J Cancer Prev 2018;23:37-43)
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참고문헌 (32)
참고문헌 신청
Finkel T / 2000 / Oxidants, oxidative stress and the biology of ageing / Nature 408:239~247
Naik E / 2011 / Mitochondrial reactive oxygen species drive proinflammatory cytokine production / J Exp Med 208:417~420
Schreck R / 1991 / Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1 / EMBO J 10:2247~2258
Lo YY / 1995 / Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes / J Biol Chem 270:11727~11730
He G / 2010 / Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation / Cancer Cell 17:286~297
Naik E / 2011 / Mitochondrial reactive oxygen species drive proinflammatory cytokine production / J Exp Med 208:417~420
Schreck R / 1991 / Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1 / EMBO J 10:2247~2258
Lo YY / 1995 / Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes / J Biol Chem 270:11727~11730
He G / 2010 / Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation / Cancer Cell 17:286~297
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